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National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014

To enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notifi...

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Autores principales: Hauser, Andrea, Hofmann, Alexandra, Hanke, Kirsten, Bremer, Viviane, Bartmeyer, Barbara, Kuecherer, Claudia, Bannert, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404484/
https://www.ncbi.nlm.nih.gov/pubmed/28105988
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.2.30436
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author Hauser, Andrea
Hofmann, Alexandra
Hanke, Kirsten
Bremer, Viviane
Bartmeyer, Barbara
Kuecherer, Claudia
Bannert, Norbert
author_facet Hauser, Andrea
Hofmann, Alexandra
Hanke, Kirsten
Bremer, Viviane
Bartmeyer, Barbara
Kuecherer, Claudia
Bannert, Norbert
author_sort Hauser, Andrea
collection PubMed
description To enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the pol region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p < 0.05). Non-B subtypes were also more frequently found in patients originating from countries other than Germany (46% vs 14%; p < 0.05) and in patients infected outside of Germany (63% vs 14%; p < 0.05).
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spelling pubmed-54044842017-05-15 National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014 Hauser, Andrea Hofmann, Alexandra Hanke, Kirsten Bremer, Viviane Bartmeyer, Barbara Kuecherer, Claudia Bannert, Norbert Euro Surveill Surveillance and Outbreak Report To enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the pol region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p < 0.05). Non-B subtypes were also more frequently found in patients originating from countries other than Germany (46% vs 14%; p < 0.05) and in patients infected outside of Germany (63% vs 14%; p < 0.05). European Centre for Disease Prevention and Control (ECDC) 2017-01-12 /pmc/articles/PMC5404484/ /pubmed/28105988 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.2.30436 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Hauser, Andrea
Hofmann, Alexandra
Hanke, Kirsten
Bremer, Viviane
Bartmeyer, Barbara
Kuecherer, Claudia
Bannert, Norbert
National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
title National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
title_full National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
title_fullStr National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
title_full_unstemmed National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
title_short National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
title_sort national molecular surveillance of recently acquired hiv infections in germany, 2013 to 2014
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404484/
https://www.ncbi.nlm.nih.gov/pubmed/28105988
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.2.30436
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