In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

The profile of PC945, a novel triazole antifungal designed for administration via inhalation, was assessed in a range of in vitro and in vivo studies. PC945 was characterized as a potent, tightly binding inhibitor of Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) activity (50% inhi...

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Detalles Bibliográficos
Autores principales: Colley, Thomas, Alanio, Alexandre, Kelly, Steven L., Sehra, Gurpreet, Kizawa, Yasuo, Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Anderson-Dring, Lauren, Nakaoki, Takahiro, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, Cooke, Michael, Bretagne, Stéphane, King-Underwood, John, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404542/
https://www.ncbi.nlm.nih.gov/pubmed/28223388
http://dx.doi.org/10.1128/AAC.02280-16

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