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In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir

Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with 50% effective concentration (EC(50)) values ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. Pibrentasvir demonstrated similar activity against a panel of chimeric r...

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Detalles Bibliográficos
Autores principales:	Ng, Teresa I., Krishnan, Preethi, Pilot-Matias, Tami, Kati, Warren, Schnell, Gretja, Beyer, Jill, Reisch, Thomas, Lu, Liangjun, Dekhtyar, Tatyana, Irvin, Michelle, Tripathi, Rakesh, Maring, Clarence, Randolph, John T., Wagner, Rolf, Collins, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404558/ https://www.ncbi.nlm.nih.gov/pubmed/28193664 http://dx.doi.org/10.1128/AAC.02558-16

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