Cargando…
Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus
This study aims to investigate the fetal outcomes and associated factors of adverse pregnancy outcomes (APOs) in pregnant women with systemic lupus erythematosus (SLE). Clinical data from 251 SLE patients with 263 pregnancies from 2001 to 2015 were analyzed retrospectively. APOs occurred in 70.0% of...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404768/ https://www.ncbi.nlm.nih.gov/pubmed/28441446 http://dx.doi.org/10.1371/journal.pone.0176457 |
_version_ | 1783231645005905920 |
---|---|
author | Zhan, Zhongping Yang, Ying Zhan, Yanfeng Chen, Dongying Liang, Liuqin Yang, Xiuyan |
author_facet | Zhan, Zhongping Yang, Ying Zhan, Yanfeng Chen, Dongying Liang, Liuqin Yang, Xiuyan |
author_sort | Zhan, Zhongping |
collection | PubMed |
description | This study aims to investigate the fetal outcomes and associated factors of adverse pregnancy outcomes (APOs) in pregnant women with systemic lupus erythematosus (SLE). Clinical data from 251 SLE patients with 263 pregnancies from 2001 to 2015 were analyzed retrospectively. APOs occurred in 70.0% of pregnancies, in which pregnancy loss occurred in 28.5%; preterm delivery occurred in 21.3%; intrauterine growth retardation occurred in 12.2%; and fetal distress occurred in 8.0%. Over time, the rate of APOs decreased from 82.8% during 2001~2005 to 59.6% during 2011~2015. In multivariate analysis, predictors of APOs included positive antiphospholipid antibodies (OR 8.4, 95% CI 1.7~40.8, P = 0.008), lower complement (OR 3.6, 95% CI 1.3~9.9, P = 0.01), hypoalbuminemia (OR 3.2, 95% CI 1.2~8.3, P = 0.02), and hypertension (OR 14.6, 95% CI 1.5~141.6, P = 0.02). The use of antimalarial medications was associated with lower risk for APOs (OR 0.3, 95% CI 0.1~0.7, P = 0.01). In total, 109 patients underwent fetal umbilical artery Doppler in the third trimester. The The adjusted systole/diastole (S/D) ratio, pulsatility index (PI) and resistance index (RI) of SLE patients with APOs were higher than that of patients without APOs (2.9±0.9 vs. 2.4±0.5, P = 0.001). Lupus pregnancy was still at high risk of APOs in terms of pregnancy loss and preterm delivery. Umbilical artery Doppler was a good monitor method for APOs in the third trimester. |
format | Online Article Text |
id | pubmed-5404768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54047682017-05-12 Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus Zhan, Zhongping Yang, Ying Zhan, Yanfeng Chen, Dongying Liang, Liuqin Yang, Xiuyan PLoS One Research Article This study aims to investigate the fetal outcomes and associated factors of adverse pregnancy outcomes (APOs) in pregnant women with systemic lupus erythematosus (SLE). Clinical data from 251 SLE patients with 263 pregnancies from 2001 to 2015 were analyzed retrospectively. APOs occurred in 70.0% of pregnancies, in which pregnancy loss occurred in 28.5%; preterm delivery occurred in 21.3%; intrauterine growth retardation occurred in 12.2%; and fetal distress occurred in 8.0%. Over time, the rate of APOs decreased from 82.8% during 2001~2005 to 59.6% during 2011~2015. In multivariate analysis, predictors of APOs included positive antiphospholipid antibodies (OR 8.4, 95% CI 1.7~40.8, P = 0.008), lower complement (OR 3.6, 95% CI 1.3~9.9, P = 0.01), hypoalbuminemia (OR 3.2, 95% CI 1.2~8.3, P = 0.02), and hypertension (OR 14.6, 95% CI 1.5~141.6, P = 0.02). The use of antimalarial medications was associated with lower risk for APOs (OR 0.3, 95% CI 0.1~0.7, P = 0.01). In total, 109 patients underwent fetal umbilical artery Doppler in the third trimester. The The adjusted systole/diastole (S/D) ratio, pulsatility index (PI) and resistance index (RI) of SLE patients with APOs were higher than that of patients without APOs (2.9±0.9 vs. 2.4±0.5, P = 0.001). Lupus pregnancy was still at high risk of APOs in terms of pregnancy loss and preterm delivery. Umbilical artery Doppler was a good monitor method for APOs in the third trimester. Public Library of Science 2017-04-25 /pmc/articles/PMC5404768/ /pubmed/28441446 http://dx.doi.org/10.1371/journal.pone.0176457 Text en © 2017 Zhan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhan, Zhongping Yang, Ying Zhan, Yanfeng Chen, Dongying Liang, Liuqin Yang, Xiuyan Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus |
title | Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus |
title_full | Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus |
title_fullStr | Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus |
title_full_unstemmed | Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus |
title_short | Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus |
title_sort | fetal outcomes and associated factors of adverse outcomes of pregnancy in southern chinese women with systemic lupus erythematosus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404768/ https://www.ncbi.nlm.nih.gov/pubmed/28441446 http://dx.doi.org/10.1371/journal.pone.0176457 |
work_keys_str_mv | AT zhanzhongping fetaloutcomesandassociatedfactorsofadverseoutcomesofpregnancyinsouthernchinesewomenwithsystemiclupuserythematosus AT yangying fetaloutcomesandassociatedfactorsofadverseoutcomesofpregnancyinsouthernchinesewomenwithsystemiclupuserythematosus AT zhanyanfeng fetaloutcomesandassociatedfactorsofadverseoutcomesofpregnancyinsouthernchinesewomenwithsystemiclupuserythematosus AT chendongying fetaloutcomesandassociatedfactorsofadverseoutcomesofpregnancyinsouthernchinesewomenwithsystemiclupuserythematosus AT liangliuqin fetaloutcomesandassociatedfactorsofadverseoutcomesofpregnancyinsouthernchinesewomenwithsystemiclupuserythematosus AT yangxiuyan fetaloutcomesandassociatedfactorsofadverseoutcomesofpregnancyinsouthernchinesewomenwithsystemiclupuserythematosus |