Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G(0)/G(1) Arrest by Inhibiting Deubiquitinase USP2a

USP2a is a deubiquitinase responsible for stabilization of cyclin D1, a crucial regulator of cell-cycle progression and a proto-oncoprotein overexpressed in numerous cancer types. Here we report that lithocholic acid (LCA) derivatives are inhibitors of USP proteins, including USP2a. The most potent...

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Detalles Bibliográficos
Autores principales: Magiera, Katarzyna, Tomala, Marcin, Kubica, Katarzyna, De Cesare, Virginia, Trost, Matthias, Zieba, Bartosz J., Kachamakova-Trojanowska, Neli, Les, Marcin, Dubin, Grzegorz, Holak, Tad A., Skalniak, Lukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404848/
https://www.ncbi.nlm.nih.gov/pubmed/28343940
http://dx.doi.org/10.1016/j.chembiol.2017.03.002

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