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Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

Phosphorylation of eIF2α controls translation initiation by restricting the levels of active eIF2-GTP/Met-tRNAi ternary complexes (TC). This modulates the expression of all eukaryotic mRNAs and contributes to the cellular integrated stress response. Key to controlling the activity of eIF2 are transl...

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Detalles Bibliográficos
Autores principales:	Jennings, Martin D, Kershaw, Christopher J, Adomavicius, Tomas, Pavitt, Graham D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404910/ https://www.ncbi.nlm.nih.gov/pubmed/28315520 http://dx.doi.org/10.7554/eLife.24542

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