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Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome. In mice, Adar1 mutations are embryonic lethal but...

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Detalles Bibliográficos
Autores principales:	Li, Yize, Banerjee, Shuvojit, Goldstein, Stephen A, Dong, Beihua, Gaughan, Christina, Rath, Sneha, Donovan, Jesse, Korennykh, Alexei, Silverman, Robert H, Weiss, Susan R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404912/ https://www.ncbi.nlm.nih.gov/pubmed/28362255 http://dx.doi.org/10.7554/eLife.25687

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