Evolution of substrate specificity in a retained enzyme driven by gene loss

The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that Actinomycetaceae genomes from human cavities are undergoing...

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Detalles Bibliográficos
Autores principales: Juárez-Vázquez, Ana Lilia, Edirisinghe, Janaka N, Verduzco-Castro, Ernesto A, Michalska, Karolina, Wu, Chenggang, Noda-García, Lianet, Babnigg, Gyorgy, Endres, Michael, Medina-Ruíz, Sofía, Santoyo-Flores, Julián, Carrillo-Tripp, Mauricio, Ton-That, Hung, Joachimiak, Andrzej, Henry, Christopher S, Barona-Gómez, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404923/
https://www.ncbi.nlm.nih.gov/pubmed/28362260
http://dx.doi.org/10.7554/eLife.22679

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