Cargando…

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

Microglia are the resident inflammatory cells of the central nervous system (CNS) and have important roles in development, homeostasis and a variety of neurologic and psychiatric diseases. Difficulties in procuring human microglia have limited their study and hampered the clinical translation of mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pandya, Hetal, Shen, Michael J., Ichikawa, David M., Sedlock, Andrea B., Choi, Yong, Johnson, Kory R., Kim, Gloria, Brown, Mason A., Elkhaloun, Abdel G., Maric, Dragan, Sweeney, Colin L., Gossa, Selamawit, Malech, Harry L., McGavern, Dorian B., Park, John K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404968/ https://www.ncbi.nlm.nih.gov/pubmed/28253233 http://dx.doi.org/10.1038/nn.4534

Ejemplares similares

Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
por: Herz, Jasmin, et al.
Publicado: (2015)

Development of an Immunologically Tolerated Combination of Fluorescent Proteins for In vivo Two-photon Imaging
por: Gossa, Selamawit, et al.
Publicado: (2014)

Early detection of cerebrovascular pathology and protective antiviral immunity by MRI
por: Liu, Li, et al.
Publicado: (2022)

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity
por: Rua, Rejane, et al.
Publicado: (2019)

Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
por: Shinzawa, Miho, et al.
Publicado: (2022)

The great balancing act: regulation and fate of antiviral T‐cell interactions
por: Moseman, E. Ashley, et al.
Publicado: (2013)

Antimicrobial immunity impedes CNS vascular repair following brain injury
por: Mastorakos, Panagiotis, et al.
Publicado: (2021)

Pentraxin 3 innately preps damaged tissue for wound healing
por: Rua, Rejane, et al.
Publicado: (2015)

Advances in Meningeal Immunity
por: Rua, Rejane, et al.
Publicado: (2018)

New advances in CNS immunity against viral infection
por: Manglani, Monica, et al.
Publicado: (2018)

Viral Control of Glioblastoma
por: Mihelson, Nicole, et al.
Publicado: (2021)

Immunological defense of CNS barriers against infections
por: Ampie, Leonel, et al.
Publicado: (2022)

Type I Interferon Programs Innate Myeloid Dynamics and Gene Expression in the Virally Infected Nervous System
por: Nayak, Debasis, et al.
Publicado: (2013)

MYELOMONOCYTIC CELL RECRUITMENT CAUSES FATAL CNS VASCULAR INJURY DURING ACUTE VIRAL MENINGITIS
por: Kim, Jiyun V., et al.
Publicado: (2008)

Glia limitans superficialis oxidation and breakdown promote cortical cell death after repetitive head injury
por: Mason, Hannah D., et al.
Publicado: (2021)

Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification
por: Lauterbach, Henning, et al.
Publicado: (2007)

PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity
por: Preite, Silvia, et al.
Publicado: (2019)

Prevention of CD8 T Cell Deletion during Chronic Viral Infection
por: Brooks, David G., et al.
Publicado: (2021)

In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells
por: Huang, Bonnie, et al.
Publicado: (2022)

TRANSCRANIAL AMELIORATION OF INFLAMMATION AND CELL DEATH FOLLOWING BRAIN INJURY
por: Roth, Theodore L., et al.
Publicado: (2013)

Temporally Distinct Myeloid Cell Reponses Mediate Damage and Repair After Cerebrovascular Injury
por: Mastorakos, Panagiotis, et al.
Publicado: (2021)

Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection
por: Lauterbach, Henning, et al.
Publicado: (2006)

29. ROLE OF AGE AND CNS MYELOID CELLS ON BREAST CANCER BRAIN METASTASIS
por: Lai Wu, Alex Man, et al.
Publicado: (2020)

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
por: Fahey, Laura M., et al.
Publicado: (2011)

Molecular Anatomy and Number of Antigen Specific CD8 T Cells Required to Cause Type 1 Diabetes
por: Oldstone, Michael B. A., et al.
Publicado: (2012)

IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
por: Brooks, David G., et al.
Publicado: (2008)

Migration of cytotoxic lymphocytes in cell cycle permits local MHC I–dependent control of division at sites of viral infection
por: Kang, Silvia S., et al.
Publicado: (2011)

Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8(+) T cell Persistence in Chronic Infection
por: Yao, Chen, et al.
Publicado: (2019)

Molecular analysis of the interaction of LCMV with its cellular receptor α-dystroglycan
por: Kunz, Stefan, et al.
Publicado: (2001)

BSCI-17. YOUNG AGE PROMOTES BREAST CANCER METASTASIS TO THE BRAIN
por: Wu, Alex, et al.
Publicado: (2019)

Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4(+) T cells
por: Ciucci, Thomas, et al.
Publicado: (2021)

Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4(+) T Cells
por: Magen, Assaf, et al.
Publicado: (2019)

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8(+) T cells at the expense of central memory
por: Cannons, Jennifer L., et al.
Publicado: (2021)

BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection
por: Urata, Shuzo, et al.
Publicado: (2018)

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
por: Zinselmeyer, Bernd H., et al.
Publicado: (2013)

Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients
por: Murray, Helen C., et al.
Publicado: (2022)

T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of T(H)17-induced neuroinflammation
por: Kwong, Brandon, et al.
Publicado: (2017)

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects
por: Cardoso, Filipa L, et al.
Publicado: (2015)

Development of a protein marker panel for characterization of human induced pluripotent stem cells (hiPSCs) using global quantitative proteome analysis
por: Pripuzova, Natalia S., et al.
Publicado: (2015)

Directed Differentiation of Human Pluripotent Stem Cells to Microglia
por: Douvaras, Panagiotis, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_rtf0aq2i94fnkbmns5lt7j822v