Cargando…

Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein

Recent data suggest that intraneuronal accumulation of metabolites of the amyloid β precursor protein (APP) is neurotoxic. We observed that transgenic mice overexpressing in neurons a human APP gene harboring the APP(E693Q) (Dutch) mutation have intraneuronal lysosomal accumulation of APP carboxyl-t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaur, Gurjinder, Pawlik, Monika, Gandy, Sam E., Ehrlich, Michelle E., Smiley, John F., Levy, Efrat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405008/ https://www.ncbi.nlm.nih.gov/pubmed/27777419 http://dx.doi.org/10.1038/mp.2016.189

Ejemplares similares

Extracellular vesicles: where the amyloid precursor protein carboxyl‐terminal fragments accumulate and amyloid‐β oligomerizes
por: Pérez‐González, Rocío, et al.
Publicado: (2020)

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space
por: Perez-Gonzalez, Rocio, et al.
Publicado: (2012)

Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes
por: Brewer, Gregory J., et al.
Publicado: (2020)

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta
por: Hilt, Silvia, et al.
Publicado: (2018)

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific
por: Dafnis, Ioannis, et al.
Publicado: (2016)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture
por: Skovronsky, Daniel M., et al.
Publicado: (1998)

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
por: Suelves, Nuria, et al.
Publicado: (2023)

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells
por: Kokawa, Asuka, et al.
Publicado: (2015)

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
por: Lauritzen, Inger, et al.
Publicado: (2016)

Intraneuronal β-Amyloid Accumulation: Aging HIV-1 Human and HIV-1 Transgenic Rat Brain
por: Li, Hailong, et al.
Publicado: (2022)

TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes
por: Takasugi, Nobumasa, et al.
Publicado: (2018)

Accumulation of Intraneuronal β-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses
por: Takahashi, Reisuke H., et al.
Publicado: (2013)

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing
por: Evrard, Caroline, et al.
Publicado: (2018)

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype
por: Christensen, Ditte Z., et al.
Publicado: (2010)

Cystatin C in Alzheimer's disease
por: Kaur, Gurjinder, et al.
Publicado: (2012)

Intraneuronal accumulation of amyloid-β peptides as the pathomechanism linking autism and its co-morbidities: epilepsy and self-injurious behavior — the hypothesis
por: Frackowiak, Janusz, et al.
Publicado: (2023)

Association of overexpressed carboxyl-terminal amyloid precursor protein in brains with altered glucose metabolism and liver toxicity
por: Hong, Sungguan, et al.
Publicado: (2023)

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains
por: Vaillant-Beuchot, Loan, et al.
Publicado: (2020)

Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells
por: PETERS, HALEY L., et al.
Publicado: (2012)

C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease
por: García-Ayllón, María-Salud, et al.
Publicado: (2017)

The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models
por: Bécot, Anaïs, et al.
Publicado: (2020)

Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes
por: Baldassarro, Vito Antonio, et al.
Publicado: (2017)

The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse
por: Lauritzen, Inger, et al.
Publicado: (2013)

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function
por: Zepa, Lia, et al.
Publicado: (2011)

Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer’s Disease Mouse Model
por: Pontrello, Crystal G., et al.
Publicado: (2022)

Lysosomal NEU1 deficiency affects Amyloid Precursor Protein levels and amyloid-β secretion via deregulated lysosomal exocytosis
por: Annunziata, Ida, et al.
Publicado: (2013)

New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers
por: Ochiishi, Tomoyo, et al.
Publicado: (2019)

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain
por: Welikovitch, Lindsay A., et al.
Publicado: (2020)

LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor
por: de Laat, Rian, et al.
Publicado: (2015)

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes
por: Tang, Weihao, et al.
Publicado: (2015)

Selective Aptamer‐Based Control of Intraneuronal Signaling
por: Lennarz, Sabine, et al.
Publicado: (2015)

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
por: Guix, Francesc X., et al.
Publicado: (2017)

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation
por: Piacentini, Roberto, et al.
Publicado: (2015)

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid
por: Tam, Joshua HK, et al.
Publicado: (2014)

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation
por: Edgar, James R., et al.
Publicado: (2015)

High Expression and Purification of Amino-Terminal Fragment of Human Amyloid Precursor Protein in Pichia pastoris and Partial Analysis of Its Properties
por: Li, Wei, et al.
Publicado: (2013)

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation
por: Christensen, Ditte Z., et al.
Publicado: (2014)

Synapses, Synaptic Activity and Intraneuronal Aβ in Alzheimer's Disease
por: Tampellini, Davide, et al.
Publicado: (2010)

Intraneuronal tau aggregation induces the integrated stress response in astrocytes
por: Batenburg, Kevin L, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lvo0rkmi97jfb6eboieql4k7de