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Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein

Recent data suggest that intraneuronal accumulation of metabolites of the amyloid β precursor protein (APP) is neurotoxic. We observed that transgenic mice overexpressing in neurons a human APP gene harboring the APP(E693Q) (Dutch) mutation have intraneuronal lysosomal accumulation of APP carboxyl-t...

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Detalles Bibliográficos
Autores principales:	Kaur, Gurjinder, Pawlik, Monika, Gandy, Sam E., Ehrlich, Michelle E., Smiley, John F., Levy, Efrat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405008/ https://www.ncbi.nlm.nih.gov/pubmed/27777419 http://dx.doi.org/10.1038/mp.2016.189

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