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Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia

Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In t...

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Detalles Bibliográficos
Autores principales: Gemmell, Philip, Burrage, Kevin, Rodríguez, Blanca, Quinn, T. Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405055/
https://www.ncbi.nlm.nih.gov/pubmed/27320382
http://dx.doi.org/10.1016/j.pbiomolbio.2016.06.003
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author Gemmell, Philip
Burrage, Kevin
Rodríguez, Blanca
Quinn, T. Alexander
author_facet Gemmell, Philip
Burrage, Kevin
Rodríguez, Blanca
Quinn, T. Alexander
author_sort Gemmell, Philip
collection PubMed
description Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In this paper, we first briefly review rabbit-specific computational modelling of ventricular cell electrophysiology, multi-cellular simulations including cellular heterogeneity, and acute ischemia. This mini-review is followed by an original computational investigation of variability in the electrophysiological response of two experimentally-calibrated populations of rabbit-specific ventricular myocyte action potential models to acute ischemia. We performed a systematic exploration of the response of the model populations to varying degrees of ischemia and individual ischemic parameters, to investigate their individual and combined effects on action potential duration and refractoriness. This revealed complex interactions between model population variability and ischemic factors, which combined to enhance variability during ischemia. This represents an important step towards an improved understanding of the role that physiological variability may play in electrophysiological alterations during acute ischemia.
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spelling pubmed-54050552017-05-05 Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia Gemmell, Philip Burrage, Kevin Rodríguez, Blanca Quinn, T. Alexander Prog Biophys Mol Biol Original Research Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In this paper, we first briefly review rabbit-specific computational modelling of ventricular cell electrophysiology, multi-cellular simulations including cellular heterogeneity, and acute ischemia. This mini-review is followed by an original computational investigation of variability in the electrophysiological response of two experimentally-calibrated populations of rabbit-specific ventricular myocyte action potential models to acute ischemia. We performed a systematic exploration of the response of the model populations to varying degrees of ischemia and individual ischemic parameters, to investigate their individual and combined effects on action potential duration and refractoriness. This revealed complex interactions between model population variability and ischemic factors, which combined to enhance variability during ischemia. This represents an important step towards an improved understanding of the role that physiological variability may play in electrophysiological alterations during acute ischemia. Pergamon Press 2016-07 /pmc/articles/PMC5405055/ /pubmed/27320382 http://dx.doi.org/10.1016/j.pbiomolbio.2016.06.003 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Gemmell, Philip
Burrage, Kevin
Rodríguez, Blanca
Quinn, T. Alexander
Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia
title Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia
title_full Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia
title_fullStr Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia
title_full_unstemmed Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia
title_short Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia
title_sort rabbit-specific computational modelling of ventricular cell electrophysiology: using populations of models to explore variability in the response to ischemia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405055/
https://www.ncbi.nlm.nih.gov/pubmed/27320382
http://dx.doi.org/10.1016/j.pbiomolbio.2016.06.003
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