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Hashimoto’s Thyroiditis and Autoimmune Gastritis

The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s. More recently, this association has been included in polyglandular autoimmune syndrome type IIIb, in which autoimmune thy...

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Autores principales: Cellini, Miriam, Santaguida, Maria Giulia, Virili, Camilla, Capriello, Silvia, Brusca, Nunzia, Gargano, Lucilla, Centanni, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405068/
https://www.ncbi.nlm.nih.gov/pubmed/28491051
http://dx.doi.org/10.3389/fendo.2017.00092
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author Cellini, Miriam
Santaguida, Maria Giulia
Virili, Camilla
Capriello, Silvia
Brusca, Nunzia
Gargano, Lucilla
Centanni, Marco
author_facet Cellini, Miriam
Santaguida, Maria Giulia
Virili, Camilla
Capriello, Silvia
Brusca, Nunzia
Gargano, Lucilla
Centanni, Marco
author_sort Cellini, Miriam
collection PubMed
description The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s. More recently, this association has been included in polyglandular autoimmune syndrome type IIIb, in which autoimmune thyroiditis represents the pivotal disorder. Hashimoto’s thyroiditis (HT) is the most frequent autoimmune disease, and it has been reported to be associated with gastric disorders in 10–40% of patients while about 40% of patients with autoimmune gastritis also present HT. Some intriguing similarities have been described about the pathogenic mechanism of these two disorders, involving a complex interaction among genetic, embryological, immunologic, and environmental factors. CAG is characterized by a partial or total disappearance of parietal cells implying the impairment of both hydrochloric acid and intrinsic factor production. The clinical outcome of this gastric damage is the occurrence of a hypochlorhydric-dependent iron-deficient anemia, followed by pernicious anemia concomitant with the progression to a severe gastric atrophy. Malabsorption of levothyroxine may occur as well. We have briefly summarized in this minireview the most recent achievements on this peculiar association of diseases that, in the last years, have been increasingly diagnosed.
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spelling pubmed-54050682017-05-10 Hashimoto’s Thyroiditis and Autoimmune Gastritis Cellini, Miriam Santaguida, Maria Giulia Virili, Camilla Capriello, Silvia Brusca, Nunzia Gargano, Lucilla Centanni, Marco Front Endocrinol (Lausanne) Endocrinology The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s. More recently, this association has been included in polyglandular autoimmune syndrome type IIIb, in which autoimmune thyroiditis represents the pivotal disorder. Hashimoto’s thyroiditis (HT) is the most frequent autoimmune disease, and it has been reported to be associated with gastric disorders in 10–40% of patients while about 40% of patients with autoimmune gastritis also present HT. Some intriguing similarities have been described about the pathogenic mechanism of these two disorders, involving a complex interaction among genetic, embryological, immunologic, and environmental factors. CAG is characterized by a partial or total disappearance of parietal cells implying the impairment of both hydrochloric acid and intrinsic factor production. The clinical outcome of this gastric damage is the occurrence of a hypochlorhydric-dependent iron-deficient anemia, followed by pernicious anemia concomitant with the progression to a severe gastric atrophy. Malabsorption of levothyroxine may occur as well. We have briefly summarized in this minireview the most recent achievements on this peculiar association of diseases that, in the last years, have been increasingly diagnosed. Frontiers Media S.A. 2017-04-26 /pmc/articles/PMC5405068/ /pubmed/28491051 http://dx.doi.org/10.3389/fendo.2017.00092 Text en Copyright © 2017 Cellini, Santaguida, Virili, Capriello, Brusca, Gargano and Centanni. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Cellini, Miriam
Santaguida, Maria Giulia
Virili, Camilla
Capriello, Silvia
Brusca, Nunzia
Gargano, Lucilla
Centanni, Marco
Hashimoto’s Thyroiditis and Autoimmune Gastritis
title Hashimoto’s Thyroiditis and Autoimmune Gastritis
title_full Hashimoto’s Thyroiditis and Autoimmune Gastritis
title_fullStr Hashimoto’s Thyroiditis and Autoimmune Gastritis
title_full_unstemmed Hashimoto’s Thyroiditis and Autoimmune Gastritis
title_short Hashimoto’s Thyroiditis and Autoimmune Gastritis
title_sort hashimoto’s thyroiditis and autoimmune gastritis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405068/
https://www.ncbi.nlm.nih.gov/pubmed/28491051
http://dx.doi.org/10.3389/fendo.2017.00092
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