Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease

Amyloid-ß (Aß) precursor protein (APP) metabolism engages neuronal endolysosomal pathways for Aß processing and secretion. In Alzheimer’s disease (AD), dysregulation of APP leads to excess Aß and neuronal dysfunction; suggesting that neuronal APP/Aß trafficking can be targeted for therapeutic gain....

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Detalles Bibliográficos
Autores principales: Embury, Christine M, Dyavarshetty, Bhagyalaxmi, Lu, Yaman, Wiederin, Jayme L, Ciborowski, Pawel, Gendelman, Howard E, Kiyota, Tomomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405105/
https://www.ncbi.nlm.nih.gov/pubmed/27966067
http://dx.doi.org/10.1007/s11481-016-9721-6

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