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Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

Left ventricular (LV) hypertrophy (LVH) is a heritable trait that is common in type 2 diabetes and is associated with the development of heart failure. The transcriptional factor Kruppel like factor 15 (KLF15) is expressed in the heart and acts as a repressor of cardiac hypertrophy in experimental m...

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Detalles Bibliográficos
Autores principales: Patel, Sheila K., Wai, Bryan, Lang, Chim C., Levin, Daniel, Palmer, Colin N.A., Parry, Helen M., Velkoska, Elena, Harrap, Stephen B., Srivastava, Piyush M., Burrell, Louise M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405178/
https://www.ncbi.nlm.nih.gov/pubmed/28400202
http://dx.doi.org/10.1016/j.ebiom.2017.03.036