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Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development

Maternal vitamin A intake varies but its impact on offspring metabolic health is unknown. Here we found that maternal vitamin A or retinoic acid (RA) administration expanded PDGFRα(+) adipose progenitor population in progeny, accompanied by increased blood vessel density and enhanced brown-like (bei...

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Autores principales: Wang, Bo, Fu, Xing, Liang, Xingwei, Wang, Zhixiu, Yang, Qiyuan, Zou, Tiande, Nie, Wei, Zhao, Junxing, Gao, Pengfei, Zhu, Mei-Jun, de Avila, Jeanene M., Maricelli, Joseph, Rodgers, Buel D., Du, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405191/
https://www.ncbi.nlm.nih.gov/pubmed/28408241
http://dx.doi.org/10.1016/j.ebiom.2017.03.041
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author Wang, Bo
Fu, Xing
Liang, Xingwei
Wang, Zhixiu
Yang, Qiyuan
Zou, Tiande
Nie, Wei
Zhao, Junxing
Gao, Pengfei
Zhu, Mei-Jun
de Avila, Jeanene M.
Maricelli, Joseph
Rodgers, Buel D.
Du, Min
author_facet Wang, Bo
Fu, Xing
Liang, Xingwei
Wang, Zhixiu
Yang, Qiyuan
Zou, Tiande
Nie, Wei
Zhao, Junxing
Gao, Pengfei
Zhu, Mei-Jun
de Avila, Jeanene M.
Maricelli, Joseph
Rodgers, Buel D.
Du, Min
author_sort Wang, Bo
collection PubMed
description Maternal vitamin A intake varies but its impact on offspring metabolic health is unknown. Here we found that maternal vitamin A or retinoic acid (RA) administration expanded PDGFRα(+) adipose progenitor population in progeny, accompanied by increased blood vessel density and enhanced brown-like (beige) phenotype in adipose tissue, protecting offspring from obesity. Blockage of retinoic acid signaling by either BMS493 or negative RA receptor (RARαDN) over-expression abolished the increase in blood vessel density, adipose progenitor population, and beige adipogenesis stimulated by RA. Furthermore, RA-induced beige adipogenesis was blocked following vascular endothelial growth factor receptor (VEGFR) 2 knock out in PDGFRα(+) cells, suggesting its mediatory role. Our data reveal an intrinsic link between maternal retinoid level and offspring health via promoting beige adipogenesis. Thus, enhancing maternal retinoids is an amiable therapeutic strategy to prevent obesity in offspring, especially for those born to obese mothers which account for one third of all pregnancies.
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spelling pubmed-54051912017-05-05 Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development Wang, Bo Fu, Xing Liang, Xingwei Wang, Zhixiu Yang, Qiyuan Zou, Tiande Nie, Wei Zhao, Junxing Gao, Pengfei Zhu, Mei-Jun de Avila, Jeanene M. Maricelli, Joseph Rodgers, Buel D. Du, Min EBioMedicine Research Paper Maternal vitamin A intake varies but its impact on offspring metabolic health is unknown. Here we found that maternal vitamin A or retinoic acid (RA) administration expanded PDGFRα(+) adipose progenitor population in progeny, accompanied by increased blood vessel density and enhanced brown-like (beige) phenotype in adipose tissue, protecting offspring from obesity. Blockage of retinoic acid signaling by either BMS493 or negative RA receptor (RARαDN) over-expression abolished the increase in blood vessel density, adipose progenitor population, and beige adipogenesis stimulated by RA. Furthermore, RA-induced beige adipogenesis was blocked following vascular endothelial growth factor receptor (VEGFR) 2 knock out in PDGFRα(+) cells, suggesting its mediatory role. Our data reveal an intrinsic link between maternal retinoid level and offspring health via promoting beige adipogenesis. Thus, enhancing maternal retinoids is an amiable therapeutic strategy to prevent obesity in offspring, especially for those born to obese mothers which account for one third of all pregnancies. Elsevier 2017-04-04 /pmc/articles/PMC5405191/ /pubmed/28408241 http://dx.doi.org/10.1016/j.ebiom.2017.03.041 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Wang, Bo
Fu, Xing
Liang, Xingwei
Wang, Zhixiu
Yang, Qiyuan
Zou, Tiande
Nie, Wei
Zhao, Junxing
Gao, Pengfei
Zhu, Mei-Jun
de Avila, Jeanene M.
Maricelli, Joseph
Rodgers, Buel D.
Du, Min
Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development
title Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development
title_full Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development
title_fullStr Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development
title_full_unstemmed Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development
title_short Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development
title_sort maternal retinoids increase pdgfrα(+) progenitor population and beige adipogenesis in progeny by stimulating vascular development
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405191/
https://www.ncbi.nlm.nih.gov/pubmed/28408241
http://dx.doi.org/10.1016/j.ebiom.2017.03.041
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