Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R

Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA virus that is the leading infectious cause of liver cancer...

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Detalles Bibliográficos
Autores principales: Mitchell, Jonathan K., Midkiff, Bentley R., Israelow, Benjamin, Evans, Matthew J., Lanford, Robert E., Walker, Christopher M., Lemon, Stanley M., McGivern, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405228/
https://www.ncbi.nlm.nih.gov/pubmed/28442604
http://dx.doi.org/10.1128/mBio.00121-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405228/
https://www.ncbi.nlm.nih.gov/pubmed/28442604
http://dx.doi.org/10.1128/mBio.00121-17

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