Cargando…

Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R

Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA virus that is the leading infectious cause of liver cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitchell, Jonathan K., Midkiff, Bentley R., Israelow, Benjamin, Evans, Matthew J., Lanford, Robert E., Walker, Christopher M., Lemon, Stanley M., McGivern, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405228/ https://www.ncbi.nlm.nih.gov/pubmed/28442604 http://dx.doi.org/10.1128/mBio.00121-17

Ejemplares similares

The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis
por: Lanford, Robert E, et al.
Publicado: (2017)

Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein
por: Munakata, Tsubasa, et al.
Publicado: (2007)

Class A Scavenger Receptor 1 (MSR1) Restricts Hepatitis C Virus Replication by Mediating Toll-like Receptor 3 Recognition of Viral RNAs Produced in Neighboring Cells
por: Dansako, Hiromichi, et al.
Publicado: (2013)

Chronic hepatitis C infection–induced liver fibrogenesis is associated with M2 macrophage activation
por: Bility, Moses T., et al.
Publicado: (2016)

Ribavirin Contributes to Hepatitis C Virus Suppression by Augmenting pDC Activation and Type 1 IFN Production
por: Wang, Yang, et al.
Publicado: (2015)

Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD
por: Qu, Lin, et al.
Publicado: (2011)

miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation
por: Masaki, Takahiro, et al.
Publicado: (2015)

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains
por: Benzine, Tiffany, et al.
Publicado: (2017)

Follow Up After PEG Tube Insertion
por: McGivern, Margaret
Publicado: (2007)

IRF3-mediated pathogenicity in a murine model of human hepatitis A
por: Sun, Lu, et al.
Publicado: (2021)

Ziconotide: a review of its pharmacology and use in the treatment of pain
por: McGivern, Joseph G
Publicado: (2007)

Investigating the feasibility and ethical implications of phenotypic screening using stem cell-derived tissue models to detect and manage disease
por: Harris, Alexander R., et al.
Publicado: (2022)

Student polling software: where cognitive psychology meets educational practice?
por: McGivern, Paul, et al.
Publicado: (2015)

The impact of COVID-19 on UK university students: Understanding the interconnection of issues experienced during lockdown
por: McGivern, Paul, et al.
Publicado: (2022)

The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis
por: Li, You, et al.
Publicado: (2022)

Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection
por: Zhou, Yan, et al.
Publicado: (2012)

Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein
por: Angus, Allan G. N., et al.
Publicado: (2010)

Distinct disease features of acute and persistent genotype 3 hepatitis E virus infection in immunocompetent and immunosuppressed Mongolian gerbils
por: Subramaniam, Sakthivel, et al.
Publicado: (2023)

‘Pastoral practices’ for quality improvement in a Kenyan clinical network
por: McGivern, Gerry, et al.
Publicado: (2017)

Examining clinical leadership in Kenyan public hospitals through the distributed leadership lens
por: Nzinga, Jacinta, et al.
Publicado: (2018)

Hybrid clinical-managers in Kenyan hospitals: Navigating between professional, official and practical norms
por: Nzinga, Jacinta, et al.
Publicado: (2019)

Alcohol attention bias in 14-16 year old adolescents: an eye tracking study
por: McGivern, Casey, et al.
Publicado: (2020)

Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C
por: McKnight, Kevin L., et al.
Publicado: (2020)

A case of limbic encephalitis presenting as a paraneoplastic manifestation of limited stage small cell lung cancer: a case report
por: Fahim, Ahmed, et al.
Publicado: (2010)

A Cooperative Interaction between Nontranslated RNA Sequences and NS5A Protein Promotes In Vivo Fitness of a Chimeric Hepatitis C/GB Virus B
por: Warter, Lucile, et al.
Publicado: (2009)

Mainstreaming as rhetoric or reality? Gender and global health at the World Bank
por: Winters, Janelle, et al.
Publicado: (2018)

The impact of pop-up warning messages of losses on expenditure in a simulated game of online roulette: a pilot study
por: McGivern, Paul, et al.
Publicado: (2019)

Variability in the use of pulse oximeters with children in Kenyan hospitals: A mixed-methods analysis
por: Enoch, Abigail J., et al.
Publicado: (2019)

microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV Infection
por: Spaniel, Carolyn, et al.
Publicado: (2013)

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C
por: Selitsky, Sara R., et al.
Publicado: (2015)

Sex related biases for attending to object color versus object position are reflected in reaction time and accuracy
por: McGivern, Robert F., et al.
Publicado: (2019)

Sex differences in implicit processing of allocentric relationships between objects and location in a Simon task
por: Mosso, Matthew, et al.
Publicado: (2020)

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation
por: Yamane, Daisuke, et al.
Publicado: (2014)

Men and Women Exhibit a Differential Bias for Processing Movement versus Objects
por: McGivern, Robert F., et al.
Publicado: (2012)

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1
por: Lao, Jessica P., et al.
Publicado: (2018)

NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated PKR translational inhibition
por: Feng, Hui, et al.
Publicado: (2017)

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes
por: Feng, Zongdi, et al.
Publicado: (2013)

Antibiotic cement spacer for isolated medial wall acetabular deficiency in the setting of infected hip arthroplasty
por: Weiss, Kevin S., et al.
Publicado: (2018)

Cell entry and release of quasi-enveloped human hepatitis viruses
por: Das, Anshuman, et al.
Publicado: (2023)

The Effects of Single and Combined Stressors on Daphnids—Enzyme Markers of Physiology and Metabolomics Validate the Impact of Pollution
por: Michalaki, Anna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r07liqrs1tchsu6fml24s9gkop