A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax

Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations...

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Autores principales: Willemsen, Mathijs, Dielis, Arne W. J. H., Samarska, Iryna V., Koster, Ad, van Marion, Arienne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405369/
https://www.ncbi.nlm.nih.gov/pubmed/28487786
http://dx.doi.org/10.1155/2017/1279525
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author Willemsen, Mathijs
Dielis, Arne W. J. H.
Samarska, Iryna V.
Koster, Ad
van Marion, Arienne M.
author_facet Willemsen, Mathijs
Dielis, Arne W. J. H.
Samarska, Iryna V.
Koster, Ad
van Marion, Arienne M.
author_sort Willemsen, Mathijs
collection PubMed
description Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations is common in AITL and the B-cell component may resemble Reed-Sternberg-like B-cells. Epstein-Barr virus is estimated to be present in 80–95% of AITL biopsies. Only a handful of EBV-negative AITL cases with EBV-negative RS-like B-cells have been reported over the last decade. We present a rare case of EBV-negative AITL with chylous ascites and chylothorax. Microscopic and immunohistochemical analysis revealed the presence of EBV-negative Reed-Sternberg-like B-cells in the tumor.
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spelling pubmed-54053692017-05-09 A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax Willemsen, Mathijs Dielis, Arne W. J. H. Samarska, Iryna V. Koster, Ad van Marion, Arienne M. Case Rep Hematol Case Report Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations is common in AITL and the B-cell component may resemble Reed-Sternberg-like B-cells. Epstein-Barr virus is estimated to be present in 80–95% of AITL biopsies. Only a handful of EBV-negative AITL cases with EBV-negative RS-like B-cells have been reported over the last decade. We present a rare case of EBV-negative AITL with chylous ascites and chylothorax. Microscopic and immunohistochemical analysis revealed the presence of EBV-negative Reed-Sternberg-like B-cells in the tumor. Hindawi 2017 2017-04-12 /pmc/articles/PMC5405369/ /pubmed/28487786 http://dx.doi.org/10.1155/2017/1279525 Text en Copyright © 2017 Mathijs Willemsen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Willemsen, Mathijs
Dielis, Arne W. J. H.
Samarska, Iryna V.
Koster, Ad
van Marion, Arienne M.
A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
title A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
title_full A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
title_fullStr A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
title_full_unstemmed A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
title_short A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
title_sort rare case of angioimmunoblastic t-cell lymphoma with epstein-barr virus-negative reed-sternberg-like b-cells, chylous ascites, and chylothorax
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405369/
https://www.ncbi.nlm.nih.gov/pubmed/28487786
http://dx.doi.org/10.1155/2017/1279525
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