Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users

It has been proposed that the acquisition of drug seeking is related to the development of conditioned dopamine responses in the ventral striatum. As drug use continues and becomes habit-like, conditioned responses have been shown to shift to the dorsal striatum. Here, using the PET [(11)C]racloprid...

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Autores principales: Cox, Sylvia M. L., Yau, Yvonne, Larcher, Kevin, Durand, France, Kolivakis, Theodore, Delaney, J. Scott, Dagher, Alain, Benkelfat, Chawki, Leyton, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405406/
https://www.ncbi.nlm.nih.gov/pubmed/28443614
http://dx.doi.org/10.1038/srep46665
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author Cox, Sylvia M. L.
Yau, Yvonne
Larcher, Kevin
Durand, France
Kolivakis, Theodore
Delaney, J. Scott
Dagher, Alain
Benkelfat, Chawki
Leyton, Marco
author_facet Cox, Sylvia M. L.
Yau, Yvonne
Larcher, Kevin
Durand, France
Kolivakis, Theodore
Delaney, J. Scott
Dagher, Alain
Benkelfat, Chawki
Leyton, Marco
author_sort Cox, Sylvia M. L.
collection PubMed
description It has been proposed that the acquisition of drug seeking is related to the development of conditioned dopamine responses in the ventral striatum. As drug use continues and becomes habit-like, conditioned responses have been shown to shift to the dorsal striatum. Here, using the PET [(11)C]raclopride method and highly personalized cocaine cues, we report the first evidence in humans of the dorsal dopamine response prior to the onset of addiction.
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spelling pubmed-54054062017-04-27 Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users Cox, Sylvia M. L. Yau, Yvonne Larcher, Kevin Durand, France Kolivakis, Theodore Delaney, J. Scott Dagher, Alain Benkelfat, Chawki Leyton, Marco Sci Rep Article It has been proposed that the acquisition of drug seeking is related to the development of conditioned dopamine responses in the ventral striatum. As drug use continues and becomes habit-like, conditioned responses have been shown to shift to the dorsal striatum. Here, using the PET [(11)C]raclopride method and highly personalized cocaine cues, we report the first evidence in humans of the dorsal dopamine response prior to the onset of addiction. Nature Publishing Group 2017-04-26 /pmc/articles/PMC5405406/ /pubmed/28443614 http://dx.doi.org/10.1038/srep46665 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cox, Sylvia M. L.
Yau, Yvonne
Larcher, Kevin
Durand, France
Kolivakis, Theodore
Delaney, J. Scott
Dagher, Alain
Benkelfat, Chawki
Leyton, Marco
Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users
title Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users
title_full Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users
title_fullStr Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users
title_full_unstemmed Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users
title_short Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users
title_sort cocaine cue-induced dopamine release in recreational cocaine users
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405406/
https://www.ncbi.nlm.nih.gov/pubmed/28443614
http://dx.doi.org/10.1038/srep46665
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