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Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma

Eosinophilic COPD appears to be a distinct patient subgroup with an increased corticosteroid response. Eosinophilic COPD has been labelled as part of the asthma COPD overlap syndrome (ACOS). We compared the clinical characteristics of eosinophilic COPD patients (without any clinical history of asthm...

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Autores principales: Kolsum, Umme, Ravi, Arjun, Hitchen, Paul, Maddi, Satyanarayana, Southworth, Thomas, Singh, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405469/
https://www.ncbi.nlm.nih.gov/pubmed/28446172
http://dx.doi.org/10.1186/s12931-017-0559-0
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author Kolsum, Umme
Ravi, Arjun
Hitchen, Paul
Maddi, Satyanarayana
Southworth, Thomas
Singh, Dave
author_facet Kolsum, Umme
Ravi, Arjun
Hitchen, Paul
Maddi, Satyanarayana
Southworth, Thomas
Singh, Dave
author_sort Kolsum, Umme
collection PubMed
description Eosinophilic COPD appears to be a distinct patient subgroup with an increased corticosteroid response. Eosinophilic COPD has been labelled as part of the asthma COPD overlap syndrome (ACOS). We compared the clinical characteristics of eosinophilic COPD patients (without any clinical history of asthma) and COPD patients with a childhood history of asthma. COPD patients with asthma were characterised by more allergies and more exacerbations, but less eosinophilic inflammation. While terms such as “ACOS” are used to “lump” patients together, we report distinct differences between eosinophilic COPD and COPD patients with asthma, and propose that these groups should be split rather than lumped.
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spelling pubmed-54054692017-04-27 Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma Kolsum, Umme Ravi, Arjun Hitchen, Paul Maddi, Satyanarayana Southworth, Thomas Singh, Dave Respir Res Letter to the Editor Eosinophilic COPD appears to be a distinct patient subgroup with an increased corticosteroid response. Eosinophilic COPD has been labelled as part of the asthma COPD overlap syndrome (ACOS). We compared the clinical characteristics of eosinophilic COPD patients (without any clinical history of asthma) and COPD patients with a childhood history of asthma. COPD patients with asthma were characterised by more allergies and more exacerbations, but less eosinophilic inflammation. While terms such as “ACOS” are used to “lump” patients together, we report distinct differences between eosinophilic COPD and COPD patients with asthma, and propose that these groups should be split rather than lumped. BioMed Central 2017-04-26 2017 /pmc/articles/PMC5405469/ /pubmed/28446172 http://dx.doi.org/10.1186/s12931-017-0559-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Kolsum, Umme
Ravi, Arjun
Hitchen, Paul
Maddi, Satyanarayana
Southworth, Thomas
Singh, Dave
Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
title Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
title_full Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
title_fullStr Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
title_full_unstemmed Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
title_short Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
title_sort clinical characteristics of eosinophilic copd versus copd patients with a history of asthma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405469/
https://www.ncbi.nlm.nih.gov/pubmed/28446172
http://dx.doi.org/10.1186/s12931-017-0559-0
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