Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

BACKGROUND: The study of novel sites of metabolism is important in understanding new mechanisms of biotransformation of a particular moiety by metabolic enzymes. This information is valuable in designing metabolically-stable compounds with drug-like properties. It may also provide insights into the...

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Detalles Bibliográficos
Autores principales: Apuy, Julius L., Xiang, Cathie, Franc, Sarah, Hegde, Sayee G., Hubbard, Robert, Zhao, Jingjing, Moghaddam, Mehran F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405620/
https://www.ncbi.nlm.nih.gov/pubmed/27165340
http://dx.doi.org/10.2174/1872312810666160511150558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405620/
https://www.ncbi.nlm.nih.gov/pubmed/27165340
http://dx.doi.org/10.2174/1872312810666160511150558

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