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Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation
BACKGROUND: The study of novel sites of metabolism is important in understanding new mechanisms of biotransformation of a particular moiety by metabolic enzymes. This information is valuable in designing metabolically-stable compounds with drug-like properties. It may also provide insights into the...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405620/ https://www.ncbi.nlm.nih.gov/pubmed/27165340 http://dx.doi.org/10.2174/1872312810666160511150558 |