Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

BACKGROUND: A rapid and comprehensive metabolic stability screen at the top of a drug discovery flow chart serves as an effective gate in eliminating low value compounds. This imparts a significant level of efficiency and saves valuable resources. While microsomes are amenable to high throughput aut...

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Detalles Bibliográficos
Autores principales: Richardson, Samantha J., Bai, April, Kulkarni, Ashutosh A., Moghaddam, Mehran F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405623/
https://www.ncbi.nlm.nih.gov/pubmed/26902079
http://dx.doi.org/10.2174/1872312810666160223121836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405623/
https://www.ncbi.nlm.nih.gov/pubmed/26902079
http://dx.doi.org/10.2174/1872312810666160223121836

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