Synthesis of ribavirin 2’-Me-C-nucleoside analogues

An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2’-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.

Detalles Bibliográficos
Autores principales: Cosson, Fanny, Faroux, Aline, Baltaze, Jean-Pierre, Farjon, Jonathan, Guillot, Régis, Uziel, Jacques, Lubin-Germain, Nadège
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405694/
https://www.ncbi.nlm.nih.gov/pubmed/28503210
http://dx.doi.org/10.3762/bjoc.13.74
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author Cosson, Fanny
Faroux, Aline
Baltaze, Jean-Pierre
Farjon, Jonathan
Guillot, Régis
Uziel, Jacques
Lubin-Germain, Nadège
author_facet Cosson, Fanny
Faroux, Aline
Baltaze, Jean-Pierre
Farjon, Jonathan
Guillot, Régis
Uziel, Jacques
Lubin-Germain, Nadège
author_sort Cosson, Fanny
collection PubMed
description An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2’-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.
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spelling pubmed-54056942017-05-12 Synthesis of ribavirin 2’-Me-C-nucleoside analogues Cosson, Fanny Faroux, Aline Baltaze, Jean-Pierre Farjon, Jonathan Guillot, Régis Uziel, Jacques Lubin-Germain, Nadège Beilstein J Org Chem Full Research Paper An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2’-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization. Beilstein-Institut 2017-04-21 /pmc/articles/PMC5405694/ /pubmed/28503210 http://dx.doi.org/10.3762/bjoc.13.74 Text en Copyright © 2017, Cosson et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Cosson, Fanny
Faroux, Aline
Baltaze, Jean-Pierre
Farjon, Jonathan
Guillot, Régis
Uziel, Jacques
Lubin-Germain, Nadège
Synthesis of ribavirin 2’-Me-C-nucleoside analogues
title Synthesis of ribavirin 2’-Me-C-nucleoside analogues
title_full Synthesis of ribavirin 2’-Me-C-nucleoside analogues
title_fullStr Synthesis of ribavirin 2’-Me-C-nucleoside analogues
title_full_unstemmed Synthesis of ribavirin 2’-Me-C-nucleoside analogues
title_short Synthesis of ribavirin 2’-Me-C-nucleoside analogues
title_sort synthesis of ribavirin 2’-me-c-nucleoside analogues
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405694/
https://www.ncbi.nlm.nih.gov/pubmed/28503210
http://dx.doi.org/10.3762/bjoc.13.74
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