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Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review
Background: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405794/ https://www.ncbi.nlm.nih.gov/pubmed/28503297 http://dx.doi.org/10.12688/f1000research.11078.2 |
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author | Alvarez, María Fernanda Bolívar-Mejía, Adrián Rodriguez-Morales, Alfonso J. Ramirez-Vallejo, Eduardo |
author_facet | Alvarez, María Fernanda Bolívar-Mejía, Adrián Rodriguez-Morales, Alfonso J. Ramirez-Vallejo, Eduardo |
author_sort | Alvarez, María Fernanda |
collection | PubMed |
description | Background: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations. No previous systemic reviews have been found in major databases about it. Methods: We performed a systematic review looking for reports about cardiovascular compromise during chikungunya disease. Cardiac compromise is not so common in isolated episodes; but countries where chikungunya virus is an epidemic should be well informed about this condition. We used 6 bibliographical databases as resources: Medline/Pubmed, Embase, ScienceDirect, ClinicalKey, Ovid and SciELO. Dengue reports on cardiovascular compromise were included as well, to compare both arbovirus’ organic compromises. Articles that delved mainly into the rheumatic articular and cutaneous complications were not considered, as they were not in line with the purpose of this study. The type of articles included were reviews, meta-analyses, case-controls, cohort studies, case reports and case series. This systematic review does not reach or performed a meta-analysis. Results: Originally based on 737 articles, our reviewed selected 40 articles with 54.2% at least mentioning CHIKV cardiovascular compromise within the systemic compromise. Cardiovascular manifestations can be considered common and have been reported in France, India, Sri Lanka, Malaysia, Colombia, Venezuela and USA, including mainly, but no limited to: hypotension, shock and circulatory collapse, Raynaud phenomenon, arrhythmias, murmurs, myocarditis, dilated cardiomyopathy, congestive insufficiency, heart failure and altered function profile (Troponins, CPK). Conclusions: Physicians should be encouraged to keep divulgating reports on the cardiovascular involvement of chikungunya virus disease, to raise awareness and ultimately encourage suitable diagnosis and intervention worldwide. More research about cardiovascular involvement and manifestations of systemic Chikungunya virus infection is urgently needed. |
format | Online Article Text |
id | pubmed-5405794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-54057942017-05-12 Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review Alvarez, María Fernanda Bolívar-Mejía, Adrián Rodriguez-Morales, Alfonso J. Ramirez-Vallejo, Eduardo F1000Res Systematic Review Background: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations. No previous systemic reviews have been found in major databases about it. Methods: We performed a systematic review looking for reports about cardiovascular compromise during chikungunya disease. Cardiac compromise is not so common in isolated episodes; but countries where chikungunya virus is an epidemic should be well informed about this condition. We used 6 bibliographical databases as resources: Medline/Pubmed, Embase, ScienceDirect, ClinicalKey, Ovid and SciELO. Dengue reports on cardiovascular compromise were included as well, to compare both arbovirus’ organic compromises. Articles that delved mainly into the rheumatic articular and cutaneous complications were not considered, as they were not in line with the purpose of this study. The type of articles included were reviews, meta-analyses, case-controls, cohort studies, case reports and case series. This systematic review does not reach or performed a meta-analysis. Results: Originally based on 737 articles, our reviewed selected 40 articles with 54.2% at least mentioning CHIKV cardiovascular compromise within the systemic compromise. Cardiovascular manifestations can be considered common and have been reported in France, India, Sri Lanka, Malaysia, Colombia, Venezuela and USA, including mainly, but no limited to: hypotension, shock and circulatory collapse, Raynaud phenomenon, arrhythmias, murmurs, myocarditis, dilated cardiomyopathy, congestive insufficiency, heart failure and altered function profile (Troponins, CPK). Conclusions: Physicians should be encouraged to keep divulgating reports on the cardiovascular involvement of chikungunya virus disease, to raise awareness and ultimately encourage suitable diagnosis and intervention worldwide. More research about cardiovascular involvement and manifestations of systemic Chikungunya virus infection is urgently needed. F1000Research 2017-05-02 /pmc/articles/PMC5405794/ /pubmed/28503297 http://dx.doi.org/10.12688/f1000research.11078.2 Text en Copyright: © 2017 Alvarez MF et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions. |
spellingShingle | Systematic Review Alvarez, María Fernanda Bolívar-Mejía, Adrián Rodriguez-Morales, Alfonso J. Ramirez-Vallejo, Eduardo Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review |
title | Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review |
title_full | Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review |
title_fullStr | Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review |
title_full_unstemmed | Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review |
title_short | Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review |
title_sort | cardiovascular involvement and manifestations of systemic chikungunya virus infection: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405794/ https://www.ncbi.nlm.nih.gov/pubmed/28503297 http://dx.doi.org/10.12688/f1000research.11078.2 |
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