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Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency

Discovering a new cell transplantation approach for treating chronic renal insufficiency is a goal of many nephrologists. In vitro-cultured peripheral blood mononuclear cells (PBMCs) were reprogrammed into induced mesenchymal stem cells (iMSCs) by using natural inducing agents made in our laboratory...

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Detalles Bibliográficos
Autores principales: Pan, Xing-hua, Zhou, Jing, Yao, Xiang, Shu, Jun, Liu, Ju-fen, Yang, Jian-yong, Pang, Rong-qing, Ruan, Guang-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405955/
https://www.ncbi.nlm.nih.gov/pubmed/28445516
http://dx.doi.org/10.1371/journal.pone.0176273
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author Pan, Xing-hua
Zhou, Jing
Yao, Xiang
Shu, Jun
Liu, Ju-fen
Yang, Jian-yong
Pang, Rong-qing
Ruan, Guang-ping
author_facet Pan, Xing-hua
Zhou, Jing
Yao, Xiang
Shu, Jun
Liu, Ju-fen
Yang, Jian-yong
Pang, Rong-qing
Ruan, Guang-ping
author_sort Pan, Xing-hua
collection PubMed
description Discovering a new cell transplantation approach for treating chronic renal insufficiency is a goal of many nephrologists. In vitro-cultured peripheral blood mononuclear cells (PBMCs) were reprogrammed into induced mesenchymal stem cells (iMSCs) by using natural inducing agents made in our laboratory. The stem cell phenotype of the iMSCs was then identified. Unilateral ureteral obstruction (UUO) was used to create an animal model of chronic renal insufficiency characterized by renal interstitial fibrosis. The induced and non-induced PBMCs were transplanted, and the efficacy of iMSCs in treating chronic renal insufficiency was evaluated using a variety of methods. The ultimate goal was to explore the effects of iMSC transplantation on the treatment of chronic renal insufficiency, with the aim of providing a new therapeutic modality for this disease.
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spelling pubmed-54059552017-05-14 Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency Pan, Xing-hua Zhou, Jing Yao, Xiang Shu, Jun Liu, Ju-fen Yang, Jian-yong Pang, Rong-qing Ruan, Guang-ping PLoS One Research Article Discovering a new cell transplantation approach for treating chronic renal insufficiency is a goal of many nephrologists. In vitro-cultured peripheral blood mononuclear cells (PBMCs) were reprogrammed into induced mesenchymal stem cells (iMSCs) by using natural inducing agents made in our laboratory. The stem cell phenotype of the iMSCs was then identified. Unilateral ureteral obstruction (UUO) was used to create an animal model of chronic renal insufficiency characterized by renal interstitial fibrosis. The induced and non-induced PBMCs were transplanted, and the efficacy of iMSCs in treating chronic renal insufficiency was evaluated using a variety of methods. The ultimate goal was to explore the effects of iMSC transplantation on the treatment of chronic renal insufficiency, with the aim of providing a new therapeutic modality for this disease. Public Library of Science 2017-04-26 /pmc/articles/PMC5405955/ /pubmed/28445516 http://dx.doi.org/10.1371/journal.pone.0176273 Text en © 2017 Pan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pan, Xing-hua
Zhou, Jing
Yao, Xiang
Shu, Jun
Liu, Ju-fen
Yang, Jian-yong
Pang, Rong-qing
Ruan, Guang-ping
Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
title Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
title_full Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
title_fullStr Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
title_full_unstemmed Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
title_short Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
title_sort transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405955/
https://www.ncbi.nlm.nih.gov/pubmed/28445516
http://dx.doi.org/10.1371/journal.pone.0176273
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