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Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

BACKGROUND: The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol(™)) in cats. METHODS: Six healthy cats (4.9 ± 0.7 kg) were included in a prospective, randomized, blin...

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Detalles Bibliográficos
Autores principales:	Doodnaught, Graeme M., Monteiro, Beatriz P., Benito, Javier, Edge, Daniel, Beaudry, Francis, Pelligand, Ludovic, Steagall, Paulo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405979/ https://www.ncbi.nlm.nih.gov/pubmed/28445495 http://dx.doi.org/10.1371/journal.pone.0176443

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