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Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dia...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406024/ https://www.ncbi.nlm.nih.gov/pubmed/28445520 http://dx.doi.org/10.1371/journal.pone.0176137 |
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author | Tan, Zhijun Ye, Zengchun Zhang, Jun Chen, Yanru Cheng, Cailian Wang, Cheng Liu, Xun Lou, Tanqi Peng, Hui |
author_facet | Tan, Zhijun Ye, Zengchun Zhang, Jun Chen, Yanru Cheng, Cailian Wang, Cheng Liu, Xun Lou, Tanqi Peng, Hui |
author_sort | Tan, Zhijun |
collection | PubMed |
description | BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. METHODS: A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentration was assessed by enzyme-linked immunosorbent assay. The correlations between serum irisin and dialysis adequacy, clinical, and metabolic variables were investigated. RESULTS: Serum irisin levels were lower in nondiabetic peritoneal dialysis patients (17.02ng/ml) compared with healthy controls (22.17ng/ml, P<0.001). Multivariate regression analysis revealed that fasting glucose levels were correlated inversely with serum irisin levels in peritoneal dialysis patients. Serum irisin levels were associated with neither insulin resistance nor bone metabolism in our patients. Serum irisin levels were positively associated with peritoneal Kt/V(urea) (β = 4.933, 95% confidence interval [CI] = 0.536–9.331, P = 0.029) and peritoneal C(Cr) (β = 0.259, 95% CI = 0.053–0.465, P = 0.015) among peritoneal dialysis patients. CONCLUSIONS: The study demonstrated that non-diabetic peritoneal dialysis patients have lower serum irisin levels, and the levels were correlated with peritoneal dialysis adequacy, indicating adequate dialysis may improve irisin secretion. Additional studies are needed to provide a confirmation. |
format | Online Article Text |
id | pubmed-5406024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54060242017-05-14 Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients Tan, Zhijun Ye, Zengchun Zhang, Jun Chen, Yanru Cheng, Cailian Wang, Cheng Liu, Xun Lou, Tanqi Peng, Hui PLoS One Research Article BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. METHODS: A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentration was assessed by enzyme-linked immunosorbent assay. The correlations between serum irisin and dialysis adequacy, clinical, and metabolic variables were investigated. RESULTS: Serum irisin levels were lower in nondiabetic peritoneal dialysis patients (17.02ng/ml) compared with healthy controls (22.17ng/ml, P<0.001). Multivariate regression analysis revealed that fasting glucose levels were correlated inversely with serum irisin levels in peritoneal dialysis patients. Serum irisin levels were associated with neither insulin resistance nor bone metabolism in our patients. Serum irisin levels were positively associated with peritoneal Kt/V(urea) (β = 4.933, 95% confidence interval [CI] = 0.536–9.331, P = 0.029) and peritoneal C(Cr) (β = 0.259, 95% CI = 0.053–0.465, P = 0.015) among peritoneal dialysis patients. CONCLUSIONS: The study demonstrated that non-diabetic peritoneal dialysis patients have lower serum irisin levels, and the levels were correlated with peritoneal dialysis adequacy, indicating adequate dialysis may improve irisin secretion. Additional studies are needed to provide a confirmation. Public Library of Science 2017-04-26 /pmc/articles/PMC5406024/ /pubmed/28445520 http://dx.doi.org/10.1371/journal.pone.0176137 Text en © 2017 Tan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Tan, Zhijun Ye, Zengchun Zhang, Jun Chen, Yanru Cheng, Cailian Wang, Cheng Liu, Xun Lou, Tanqi Peng, Hui Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients |
title | Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients |
title_full | Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients |
title_fullStr | Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients |
title_full_unstemmed | Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients |
title_short | Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients |
title_sort | serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406024/ https://www.ncbi.nlm.nih.gov/pubmed/28445520 http://dx.doi.org/10.1371/journal.pone.0176137 |
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