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Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients

BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dia...

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Autores principales: Tan, Zhijun, Ye, Zengchun, Zhang, Jun, Chen, Yanru, Cheng, Cailian, Wang, Cheng, Liu, Xun, Lou, Tanqi, Peng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406024/
https://www.ncbi.nlm.nih.gov/pubmed/28445520
http://dx.doi.org/10.1371/journal.pone.0176137
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author Tan, Zhijun
Ye, Zengchun
Zhang, Jun
Chen, Yanru
Cheng, Cailian
Wang, Cheng
Liu, Xun
Lou, Tanqi
Peng, Hui
author_facet Tan, Zhijun
Ye, Zengchun
Zhang, Jun
Chen, Yanru
Cheng, Cailian
Wang, Cheng
Liu, Xun
Lou, Tanqi
Peng, Hui
author_sort Tan, Zhijun
collection PubMed
description BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. METHODS: A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentration was assessed by enzyme-linked immunosorbent assay. The correlations between serum irisin and dialysis adequacy, clinical, and metabolic variables were investigated. RESULTS: Serum irisin levels were lower in nondiabetic peritoneal dialysis patients (17.02ng/ml) compared with healthy controls (22.17ng/ml, P<0.001). Multivariate regression analysis revealed that fasting glucose levels were correlated inversely with serum irisin levels in peritoneal dialysis patients. Serum irisin levels were associated with neither insulin resistance nor bone metabolism in our patients. Serum irisin levels were positively associated with peritoneal Kt/V(urea) (β = 4.933, 95% confidence interval [CI] = 0.536–9.331, P = 0.029) and peritoneal C(Cr) (β = 0.259, 95% CI = 0.053–0.465, P = 0.015) among peritoneal dialysis patients. CONCLUSIONS: The study demonstrated that non-diabetic peritoneal dialysis patients have lower serum irisin levels, and the levels were correlated with peritoneal dialysis adequacy, indicating adequate dialysis may improve irisin secretion. Additional studies are needed to provide a confirmation.
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spelling pubmed-54060242017-05-14 Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients Tan, Zhijun Ye, Zengchun Zhang, Jun Chen, Yanru Cheng, Cailian Wang, Cheng Liu, Xun Lou, Tanqi Peng, Hui PLoS One Research Article BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. METHODS: A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentration was assessed by enzyme-linked immunosorbent assay. The correlations between serum irisin and dialysis adequacy, clinical, and metabolic variables were investigated. RESULTS: Serum irisin levels were lower in nondiabetic peritoneal dialysis patients (17.02ng/ml) compared with healthy controls (22.17ng/ml, P<0.001). Multivariate regression analysis revealed that fasting glucose levels were correlated inversely with serum irisin levels in peritoneal dialysis patients. Serum irisin levels were associated with neither insulin resistance nor bone metabolism in our patients. Serum irisin levels were positively associated with peritoneal Kt/V(urea) (β = 4.933, 95% confidence interval [CI] = 0.536–9.331, P = 0.029) and peritoneal C(Cr) (β = 0.259, 95% CI = 0.053–0.465, P = 0.015) among peritoneal dialysis patients. CONCLUSIONS: The study demonstrated that non-diabetic peritoneal dialysis patients have lower serum irisin levels, and the levels were correlated with peritoneal dialysis adequacy, indicating adequate dialysis may improve irisin secretion. Additional studies are needed to provide a confirmation. Public Library of Science 2017-04-26 /pmc/articles/PMC5406024/ /pubmed/28445520 http://dx.doi.org/10.1371/journal.pone.0176137 Text en © 2017 Tan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tan, Zhijun
Ye, Zengchun
Zhang, Jun
Chen, Yanru
Cheng, Cailian
Wang, Cheng
Liu, Xun
Lou, Tanqi
Peng, Hui
Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
title Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
title_full Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
title_fullStr Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
title_full_unstemmed Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
title_short Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
title_sort serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406024/
https://www.ncbi.nlm.nih.gov/pubmed/28445520
http://dx.doi.org/10.1371/journal.pone.0176137
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