Cargando…

Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription

OBJECTIVES: To describe a case of neuroleptic malignant syndrome following antipsychotic treatment of catatonia, highlighting the potentially serious complications of this rare adverse drug reaction. METHODS: We present a case report of a patient who developed this syndrome with various sequelae. RE...

Descripción completa

Detalles Bibliográficos
Autores principales: Reilly, Thomas J, Cross, Sean, Taylor, David M, Haslam, Richard, Tomlin, Sophie C, Gaastra, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406192/
https://www.ncbi.nlm.nih.gov/pubmed/28491312
http://dx.doi.org/10.1177/2050313X17695999
_version_ 1783231922090016768
author Reilly, Thomas J
Cross, Sean
Taylor, David M
Haslam, Richard
Tomlin, Sophie C
Gaastra, Benjamin
author_facet Reilly, Thomas J
Cross, Sean
Taylor, David M
Haslam, Richard
Tomlin, Sophie C
Gaastra, Benjamin
author_sort Reilly, Thomas J
collection PubMed
description OBJECTIVES: To describe a case of neuroleptic malignant syndrome following antipsychotic treatment of catatonia, highlighting the potentially serious complications of this rare adverse drug reaction. METHODS: We present a case report of a patient who developed this syndrome with various sequelae. RESULTS: The patient developed neuroleptic after being treated with lorazepam and olanzapine for catatonia. He subsequently developed the complications of rhabdomyolysis, acute kidney injury, pulmonary embolism, urinary retention and ileus. He received high-dose lorazepam, anticoagulation and intravenous fluids. Antipsychotic medication in the form of haloperidol was reinstated with no adverse effect, and he went on to make a full recovery. CONCLUSIONS: This case illustrates the potential life-threatening complications of neuroleptic malignant syndrome and the need for a low index of clinical suspicion. It also highlights the lack of evidence for treatment of catatonia, including the use of antipsychotics.
format Online
Article
Text
id pubmed-5406192
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-54061922017-05-10 Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription Reilly, Thomas J Cross, Sean Taylor, David M Haslam, Richard Tomlin, Sophie C Gaastra, Benjamin SAGE Open Med Case Rep Case Report OBJECTIVES: To describe a case of neuroleptic malignant syndrome following antipsychotic treatment of catatonia, highlighting the potentially serious complications of this rare adverse drug reaction. METHODS: We present a case report of a patient who developed this syndrome with various sequelae. RESULTS: The patient developed neuroleptic after being treated with lorazepam and olanzapine for catatonia. He subsequently developed the complications of rhabdomyolysis, acute kidney injury, pulmonary embolism, urinary retention and ileus. He received high-dose lorazepam, anticoagulation and intravenous fluids. Antipsychotic medication in the form of haloperidol was reinstated with no adverse effect, and he went on to make a full recovery. CONCLUSIONS: This case illustrates the potential life-threatening complications of neuroleptic malignant syndrome and the need for a low index of clinical suspicion. It also highlights the lack of evidence for treatment of catatonia, including the use of antipsychotics. SAGE Publications 2017-03-31 /pmc/articles/PMC5406192/ /pubmed/28491312 http://dx.doi.org/10.1177/2050313X17695999 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Reilly, Thomas J
Cross, Sean
Taylor, David M
Haslam, Richard
Tomlin, Sophie C
Gaastra, Benjamin
Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription
title Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription
title_full Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription
title_fullStr Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription
title_full_unstemmed Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription
title_short Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription
title_sort neuroleptic malignant syndrome following catatonia: vigilance is the price of antipsychotic prescription
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406192/
https://www.ncbi.nlm.nih.gov/pubmed/28491312
http://dx.doi.org/10.1177/2050313X17695999
work_keys_str_mv AT reillythomasj neurolepticmalignantsyndromefollowingcatatoniavigilanceisthepriceofantipsychoticprescription
AT crosssean neurolepticmalignantsyndromefollowingcatatoniavigilanceisthepriceofantipsychoticprescription
AT taylordavidm neurolepticmalignantsyndromefollowingcatatoniavigilanceisthepriceofantipsychoticprescription
AT haslamrichard neurolepticmalignantsyndromefollowingcatatoniavigilanceisthepriceofantipsychoticprescription
AT tomlinsophiec neurolepticmalignantsyndromefollowingcatatoniavigilanceisthepriceofantipsychoticprescription
AT gaastrabenjamin neurolepticmalignantsyndromefollowingcatatoniavigilanceisthepriceofantipsychoticprescription