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Brachytherapy and anterior segment imaging in iris melanoma

A 40-year-old male presented to the ophthalmology clinic with a darkly pigmented infratemporal lesion in his right eye. The corrected visual acuity in both eyes was 6/6 and both pupils were equal and reactive. Slit lamp biomicroscopy showed a well-demarcated and heavily pigmented lesion in the perip...

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Autores principales: Song, Jin Soo Andy, Dmytriw, Adam A, Lakosha, Hesham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406218/
https://www.ncbi.nlm.nih.gov/pubmed/28487752
http://dx.doi.org/10.3332/ecancer.2017.734
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author Song, Jin Soo Andy
Dmytriw, Adam A
Lakosha, Hesham
author_facet Song, Jin Soo Andy
Dmytriw, Adam A
Lakosha, Hesham
author_sort Song, Jin Soo Andy
collection PubMed
description A 40-year-old male presented to the ophthalmology clinic with a darkly pigmented infratemporal lesion in his right eye. The corrected visual acuity in both eyes was 6/6 and both pupils were equal and reactive. Slit lamp biomicroscopy showed a well-demarcated and heavily pigmented lesion in the peripheral iris between 6 and 8 o’clock. Ultrasound biomicroscopy (UBM) revealed a solid mass deriving from the iris stroma without ciliary body involvement, helping to classify the uveal melanoma and establishing the diagnosis of iris melanoma. Fine needle aspiration (FNA) confirmed melanoma with inactivation of the BAP1 gene. The patient was treated with brachytherapy using an I-125 plaque. Follow-up UBM, three years later, demonstrated significantly reduced dimensions of the tumour. UBM has become crucial to the differentiation of uveal melanomas from benign growths, and lesions <3 mm cannot be reliably visualised by other imaging modalities or localised to the correct uveal structure. Brachytherapy represents a safe and effective treatment option even in lesions that are BAP1 positive.
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spelling pubmed-54062182017-05-09 Brachytherapy and anterior segment imaging in iris melanoma Song, Jin Soo Andy Dmytriw, Adam A Lakosha, Hesham Ecancermedicalscience Image Report A 40-year-old male presented to the ophthalmology clinic with a darkly pigmented infratemporal lesion in his right eye. The corrected visual acuity in both eyes was 6/6 and both pupils were equal and reactive. Slit lamp biomicroscopy showed a well-demarcated and heavily pigmented lesion in the peripheral iris between 6 and 8 o’clock. Ultrasound biomicroscopy (UBM) revealed a solid mass deriving from the iris stroma without ciliary body involvement, helping to classify the uveal melanoma and establishing the diagnosis of iris melanoma. Fine needle aspiration (FNA) confirmed melanoma with inactivation of the BAP1 gene. The patient was treated with brachytherapy using an I-125 plaque. Follow-up UBM, three years later, demonstrated significantly reduced dimensions of the tumour. UBM has become crucial to the differentiation of uveal melanomas from benign growths, and lesions <3 mm cannot be reliably visualised by other imaging modalities or localised to the correct uveal structure. Brachytherapy represents a safe and effective treatment option even in lesions that are BAP1 positive. Cancer Intelligence 2017-04-18 /pmc/articles/PMC5406218/ /pubmed/28487752 http://dx.doi.org/10.3332/ecancer.2017.734 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Image Report
Song, Jin Soo Andy
Dmytriw, Adam A
Lakosha, Hesham
Brachytherapy and anterior segment imaging in iris melanoma
title Brachytherapy and anterior segment imaging in iris melanoma
title_full Brachytherapy and anterior segment imaging in iris melanoma
title_fullStr Brachytherapy and anterior segment imaging in iris melanoma
title_full_unstemmed Brachytherapy and anterior segment imaging in iris melanoma
title_short Brachytherapy and anterior segment imaging in iris melanoma
title_sort brachytherapy and anterior segment imaging in iris melanoma
topic Image Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406218/
https://www.ncbi.nlm.nih.gov/pubmed/28487752
http://dx.doi.org/10.3332/ecancer.2017.734
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