Cargando…

Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin‐3/RXFP3 system in neuropsychiatric disorders

Relaxin‐3 has been proposed to modulate emotional–behavioural functions such as arousal and behavioural activation, appetite regulation, stress responses, anxiety, memory, sleep and circadian rhythm. The nucleus incertus (NI), in the midline tegmentum close to the fourth ventricle, projects widely t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Jigna Rajesh, Rajkumar, Ramamoorthy, Jayakody, Tharindunee, Marwari, Subhi, Hong, Jia Mei, Ma, Sherie, Gundlach, Andrew L, Lai, Mitchell K P, Dawe, Gavin S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Themed Section: Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406295/ https://www.ncbi.nlm.nih.gov/pubmed/27597467 http://dx.doi.org/10.1111/bph.13564

Ejemplares similares

Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
por: Gil-Miravet, Isis, et al.
Publicado: (2021)

Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat
por: García-Díaz, Cristina, et al.
Publicado: (2021)

Relaxin-3/RXFP3 Signaling and Neuroendocrine Function – A Perspective on Extrinsic Hypothalamic Control
por: Ganella, Despina E., et al.
Publicado: (2013)

Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function
por: Callander, Gabrielle E., et al.
Publicado: (2012)

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter
por: Wykes, Alexander D., et al.
Publicado: (2019)

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?
por: Smith, Craig M., et al.
Publicado: (2014)

Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus
por: Nasirova, Nailyam, et al.
Publicado: (2020)

GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
por: Albert-Gascó, Hector, et al.
Publicado: (2018)

Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach
por: Wong, Win Lee Edwin, et al.
Publicado: (2023)

Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice
por: Walker, Andrew W., et al.
Publicado: (2015)

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3
por: Bathgate, Ross A. D., et al.
Publicado: (2013)

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
por: Leysen, Hanne, et al.
Publicado: (2022)

Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats
por: Kim, Jae Hyung, et al.
Publicado: (2016)

Intranasal administration of a stapled relaxin‐3 mimetic has anxiolytic‐ and antidepressant‐like activity in rats
por: Marwari, Subhi, et al.
Publicado: (2019)

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design
por: D'Ercole, Annunziata, et al.
Publicado: (2022)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
por: Kocan, Martina, et al.
Publicado: (2017)

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
por: Chen, Yan, et al.
Publicado: (2023)

Relaxin'
Publicado: (1983)

Relaxin
por: DeCherney, Alan H.
Publicado: (1982)

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
por: Sethi, Ashish, et al.
Publicado: (2016)

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis
por: McBride, Andrew, et al.
Publicado: (2017)

The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
por: Chen, Ting‐Yun, et al.
Publicado: (2020)

Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat
por: Filonzi, Marcelo, et al.
Publicado: (2007)

Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents
por: Dehghan, Firouzeh, et al.
Publicado: (2016)

Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala
por: Santos, Fabio N., et al.
Publicado: (2016)

Sex-Steroid Regulation of Relaxin Receptor Isoforms (RXFP1 & RXFP2) Expression in the Patellar Tendon and Lateral Collateral Ligament of Female WKY Rats
por: Dehghan, Firouzeh, et al.
Publicado: (2014)

Postnatal development of the relaxin-3 innervation of the rat medial septum
por: Ros-Bernal, Francisco, et al.
Publicado: (2023)

Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer
por: Fue, Misaki, et al.
Publicado: (2018)

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis
por: Hoare, Bradley L., et al.
Publicado: (2018)

Characterization of relaxin 3 and its receptors in chicken: Evidence for relaxin 3 acting as a novel pituitary hormone
por: Lv, Can, et al.
Publicado: (2022)

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin
por: Bruell, Shoni, et al.
Publicado: (2017)

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
por: Hossain, Mohammed Akhter, et al.
Publicado: (2016)

The effect of relaxin on the musculoskeletal system
por: Dehghan, F, et al.
Publicado: (2014)

Characterizing relaxin receptor expression and exploring relaxin’s effect on tissue remodeling/fibrosis in the human bladder
por: Diaz, Edward C., et al.
Publicado: (2020)

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice
por: Lewis, Jo E., et al.
Publicado: (2022)

Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis
por: McGowan, B. M., et al.
Publicado: (2008)

Expression of Relaxin 3 in the Ovarian Follicle of Japanese Quail
por: Hoang, Khoi X., et al.
Publicado: (2023)

Functional Neuroanatomy of the Rat Nucleus Incertus–Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway
por: Szlaga, Agata, et al.
Publicado: (2022)

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability
por: Nair, Vinojini B., et al.
Publicado: (2015)

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex
por: Halls, Michelle L, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_itvs68tjp5608v81s85997udi7