Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans

Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy. Combining two tractable genetic models, the bacterium E. coli and the...

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Detalles Bibliográficos
Autores principales: Scott, Timothy A., Quintaneiro, Leonor M., Norvaisas, Povilas, Lui, Prudence P., Wilson, Matthew P., Leung, Kit-Yi, Herrera-Dominguez, Lucia, Sudiwala, Sonia, Pessia, Alberto, Clayton, Peter T., Bryson, Kevin, Velagapudi, Vidya, Mills, Philippa B., Typas, Athanasios, Greene, Nicholas D.E., Cabreiro, Filipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406385/
https://www.ncbi.nlm.nih.gov/pubmed/28431245
http://dx.doi.org/10.1016/j.cell.2017.03.040

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