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The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells

Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto...

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Autores principales: Andris, Fabienne, Denanglaire, Sébastien, Anciaux, Maelle, Hercor, Mélanie, Hussein, Hind, Leo, Oberdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406410/
https://www.ncbi.nlm.nih.gov/pubmed/28496444
http://dx.doi.org/10.3389/fimmu.2017.00480
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author Andris, Fabienne
Denanglaire, Sébastien
Anciaux, Maelle
Hercor, Mélanie
Hussein, Hind
Leo, Oberdan
author_facet Andris, Fabienne
Denanglaire, Sébastien
Anciaux, Maelle
Hercor, Mélanie
Hussein, Hind
Leo, Oberdan
author_sort Andris, Fabienne
collection PubMed
description Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly, c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens.
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spelling pubmed-54064102017-05-11 The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells Andris, Fabienne Denanglaire, Sébastien Anciaux, Maelle Hercor, Mélanie Hussein, Hind Leo, Oberdan Front Immunol Immunology Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly, c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens. Frontiers Media S.A. 2017-04-27 /pmc/articles/PMC5406410/ /pubmed/28496444 http://dx.doi.org/10.3389/fimmu.2017.00480 Text en Copyright © 2017 Andris, Denanglaire, Anciaux, Hercor, Hussein and Leo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Andris, Fabienne
Denanglaire, Sébastien
Anciaux, Maelle
Hercor, Mélanie
Hussein, Hind
Leo, Oberdan
The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
title The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
title_full The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
title_fullStr The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
title_full_unstemmed The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
title_short The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
title_sort transcription factor c-maf promotes the differentiation of follicular helper t cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406410/
https://www.ncbi.nlm.nih.gov/pubmed/28496444
http://dx.doi.org/10.3389/fimmu.2017.00480
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