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Cerebello-cerebral connectivity in the developing brain

Disrupted cerebellar development and injury is associated with impairments in both motor and non-motor domains. Methods to non-invasively characterize cerebellar afferent and efferent connections during early development are lacking. The aim of this study was to assess the feasibility of delineating...

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Autores principales: Pieterman, Kay, Batalle, Dafnis, Dudink, Jeroen, Tournier, J-Donald, Hughes, Emer J., Barnett, Madeleine, Benders, Manon J., Edwards, A. David, Hoebeek, Freek E., Counsell, Serena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406415/
https://www.ncbi.nlm.nih.gov/pubmed/27573027
http://dx.doi.org/10.1007/s00429-016-1296-8
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author Pieterman, Kay
Batalle, Dafnis
Dudink, Jeroen
Tournier, J-Donald
Hughes, Emer J.
Barnett, Madeleine
Benders, Manon J.
Edwards, A. David
Hoebeek, Freek E.
Counsell, Serena J.
author_facet Pieterman, Kay
Batalle, Dafnis
Dudink, Jeroen
Tournier, J-Donald
Hughes, Emer J.
Barnett, Madeleine
Benders, Manon J.
Edwards, A. David
Hoebeek, Freek E.
Counsell, Serena J.
author_sort Pieterman, Kay
collection PubMed
description Disrupted cerebellar development and injury is associated with impairments in both motor and non-motor domains. Methods to non-invasively characterize cerebellar afferent and efferent connections during early development are lacking. The aim of this study was to assess the feasibility of delineating cortico-ponto-cerebellar (CPC) and cerebello-thalamo-cortical (CTC) white matter tracts during brain development using high angular resolution diffusion imaging (HARDI). HARDI data were obtained in 24 infants born between 24(+6) and 39 weeks gestational age (median 33(+4) weeks) and scanned between 29(+1) and 44 weeks postmenstrual age (PMA) (median 37(+1) weeks). Probabilistic tractography of CPC and CTC fibers was performed using constrained spherical deconvolution. Connections between cerebellum and contralateral cerebral hemisphere were identified in all infants studied. Fractional anisotropy (FA) values of CTC and CPC pathways increased with increasing PMA at scan (p < 0.001). The supratentorial regions connecting to contralateral cerebellum in most subjects, irrespective of PMA at scan, included the precentral cortex, superior frontal cortex, supplementary motor area, insula, postcentral cortex, precuneus, and paracentral lobule. This study demonstrates the feasibility of assessing CTC and CPC white matter connectivity in vivo during the early stages of development. The ability to assess cerebellar connectivity during this critical developmental period may help improve our understanding of the role of the cerebellum in a wide range of neuromotor and neurocognitive disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1296-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-54064152017-05-12 Cerebello-cerebral connectivity in the developing brain Pieterman, Kay Batalle, Dafnis Dudink, Jeroen Tournier, J-Donald Hughes, Emer J. Barnett, Madeleine Benders, Manon J. Edwards, A. David Hoebeek, Freek E. Counsell, Serena J. Brain Struct Funct Original Article Disrupted cerebellar development and injury is associated with impairments in both motor and non-motor domains. Methods to non-invasively characterize cerebellar afferent and efferent connections during early development are lacking. The aim of this study was to assess the feasibility of delineating cortico-ponto-cerebellar (CPC) and cerebello-thalamo-cortical (CTC) white matter tracts during brain development using high angular resolution diffusion imaging (HARDI). HARDI data were obtained in 24 infants born between 24(+6) and 39 weeks gestational age (median 33(+4) weeks) and scanned between 29(+1) and 44 weeks postmenstrual age (PMA) (median 37(+1) weeks). Probabilistic tractography of CPC and CTC fibers was performed using constrained spherical deconvolution. Connections between cerebellum and contralateral cerebral hemisphere were identified in all infants studied. Fractional anisotropy (FA) values of CTC and CPC pathways increased with increasing PMA at scan (p < 0.001). The supratentorial regions connecting to contralateral cerebellum in most subjects, irrespective of PMA at scan, included the precentral cortex, superior frontal cortex, supplementary motor area, insula, postcentral cortex, precuneus, and paracentral lobule. This study demonstrates the feasibility of assessing CTC and CPC white matter connectivity in vivo during the early stages of development. The ability to assess cerebellar connectivity during this critical developmental period may help improve our understanding of the role of the cerebellum in a wide range of neuromotor and neurocognitive disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1296-8) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-08-29 2017 /pmc/articles/PMC5406415/ /pubmed/27573027 http://dx.doi.org/10.1007/s00429-016-1296-8 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Pieterman, Kay
Batalle, Dafnis
Dudink, Jeroen
Tournier, J-Donald
Hughes, Emer J.
Barnett, Madeleine
Benders, Manon J.
Edwards, A. David
Hoebeek, Freek E.
Counsell, Serena J.
Cerebello-cerebral connectivity in the developing brain
title Cerebello-cerebral connectivity in the developing brain
title_full Cerebello-cerebral connectivity in the developing brain
title_fullStr Cerebello-cerebral connectivity in the developing brain
title_full_unstemmed Cerebello-cerebral connectivity in the developing brain
title_short Cerebello-cerebral connectivity in the developing brain
title_sort cerebello-cerebral connectivity in the developing brain
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406415/
https://www.ncbi.nlm.nih.gov/pubmed/27573027
http://dx.doi.org/10.1007/s00429-016-1296-8
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