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Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells

IL-21 is known to promote anti-tumour immunity due to its ability to promote T cell responses and counteract Treg-mediated suppression. It has also been shown to limit Treg frequencies during tumour-antigen stimulations. However, whether this represents inhibition of FOXP3 induction in naïve CD4 T c...

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Detalles Bibliográficos
Autores principales:	Kannappan, Vinodh, Butcher, Kate, Trela, Malgorzata, Nicholl, Iain, Wang, Weiguang, Attridge, Kesley
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406419/ https://www.ncbi.nlm.nih.gov/pubmed/28239749 http://dx.doi.org/10.1007/s00262-017-1970-6

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