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Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406446/ https://www.ncbi.nlm.nih.gov/pubmed/27783219 http://dx.doi.org/10.1007/s00429-016-1309-7 |
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author | Lau, Petrina Yau-Pok Katona, Linda Saghy, Peter Newton, Kathryn Somogyi, Peter Lamsa, Karri P. |
author_facet | Lau, Petrina Yau-Pok Katona, Linda Saghy, Peter Newton, Kathryn Somogyi, Peter Lamsa, Karri P. |
author_sort | Lau, Petrina Yau-Pok |
collection | PubMed |
description | Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. We investigated synaptically-evoked suprathreshold excitation of identified hippocampal neurons in the CA1 area of urethane-anaesthetized rats. Neurons were recorded extracellularly with glass microelectrodes, and labelled with neurobiotin for anatomical analyses. Single-shock electrical stimulation of afferents from the contralateral CA1 elicited postsynaptic action potentials with monosynaptic features showing short delay (9.95 ± 0.41 ms) and small jitter in 13 neurons through the commissural pathway. Theta-burst stimulation (TBS) generated LTP of the synaptically-evoked spike probability in pyramidal cells, and in a bistratified cell and two unidentified fast-spiking interneurons. On the contrary, PV+ basket cells and NOS+ ivy cells exhibited either LTD or LTP. An identified axo-axonic cell failed to show long-term change in its response to stimulation. Discharge of the cells did not explain whether LTP or LTD was generated. For the fast-spiking interneurons, as a group, no correlation was found between plasticity and local field potential oscillations (1–3 or 3–6 Hz components) recorded immediately prior to TBS. The results demonstrate activity-induced long-term plasticity in synaptic excitation of hippocampal PV+ and NOS+ interneurons in vivo. Physiological and pathological activity patterns in vivo may generate similar plasticity in these interneurons. |
format | Online Article Text |
id | pubmed-5406446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-54064462017-05-12 Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo Lau, Petrina Yau-Pok Katona, Linda Saghy, Peter Newton, Kathryn Somogyi, Peter Lamsa, Karri P. Brain Struct Funct Original Article Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. We investigated synaptically-evoked suprathreshold excitation of identified hippocampal neurons in the CA1 area of urethane-anaesthetized rats. Neurons were recorded extracellularly with glass microelectrodes, and labelled with neurobiotin for anatomical analyses. Single-shock electrical stimulation of afferents from the contralateral CA1 elicited postsynaptic action potentials with monosynaptic features showing short delay (9.95 ± 0.41 ms) and small jitter in 13 neurons through the commissural pathway. Theta-burst stimulation (TBS) generated LTP of the synaptically-evoked spike probability in pyramidal cells, and in a bistratified cell and two unidentified fast-spiking interneurons. On the contrary, PV+ basket cells and NOS+ ivy cells exhibited either LTD or LTP. An identified axo-axonic cell failed to show long-term change in its response to stimulation. Discharge of the cells did not explain whether LTP or LTD was generated. For the fast-spiking interneurons, as a group, no correlation was found between plasticity and local field potential oscillations (1–3 or 3–6 Hz components) recorded immediately prior to TBS. The results demonstrate activity-induced long-term plasticity in synaptic excitation of hippocampal PV+ and NOS+ interneurons in vivo. Physiological and pathological activity patterns in vivo may generate similar plasticity in these interneurons. Springer Berlin Heidelberg 2016-10-25 2017 /pmc/articles/PMC5406446/ /pubmed/27783219 http://dx.doi.org/10.1007/s00429-016-1309-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Lau, Petrina Yau-Pok Katona, Linda Saghy, Peter Newton, Kathryn Somogyi, Peter Lamsa, Karri P. Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo |
title | Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo |
title_full | Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo |
title_fullStr | Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo |
title_full_unstemmed | Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo |
title_short | Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo |
title_sort | long-term plasticity in identified hippocampal gabaergic interneurons in the ca1 area in vivo |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406446/ https://www.ncbi.nlm.nih.gov/pubmed/27783219 http://dx.doi.org/10.1007/s00429-016-1309-7 |
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