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Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo

Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+...

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Autores principales: Lau, Petrina Yau-Pok, Katona, Linda, Saghy, Peter, Newton, Kathryn, Somogyi, Peter, Lamsa, Karri P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406446/
https://www.ncbi.nlm.nih.gov/pubmed/27783219
http://dx.doi.org/10.1007/s00429-016-1309-7
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author Lau, Petrina Yau-Pok
Katona, Linda
Saghy, Peter
Newton, Kathryn
Somogyi, Peter
Lamsa, Karri P.
author_facet Lau, Petrina Yau-Pok
Katona, Linda
Saghy, Peter
Newton, Kathryn
Somogyi, Peter
Lamsa, Karri P.
author_sort Lau, Petrina Yau-Pok
collection PubMed
description Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. We investigated synaptically-evoked suprathreshold excitation of identified hippocampal neurons in the CA1 area of urethane-anaesthetized rats. Neurons were recorded extracellularly with glass microelectrodes, and labelled with neurobiotin for anatomical analyses. Single-shock electrical stimulation of afferents from the contralateral CA1 elicited postsynaptic action potentials with monosynaptic features showing short delay (9.95 ± 0.41 ms) and small jitter in 13 neurons through the commissural pathway. Theta-burst stimulation (TBS) generated LTP of the synaptically-evoked spike probability in pyramidal cells, and in a bistratified cell and two unidentified fast-spiking interneurons. On the contrary, PV+ basket cells and NOS+ ivy cells exhibited either LTD or LTP. An identified axo-axonic cell failed to show long-term change in its response to stimulation. Discharge of the cells did not explain whether LTP or LTD was generated. For the fast-spiking interneurons, as a group, no correlation was found between plasticity and local field potential oscillations (1–3 or 3–6 Hz components) recorded immediately prior to TBS. The results demonstrate activity-induced long-term plasticity in synaptic excitation of hippocampal PV+ and NOS+ interneurons in vivo. Physiological and pathological activity patterns in vivo may generate similar plasticity in these interneurons.
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spelling pubmed-54064462017-05-12 Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo Lau, Petrina Yau-Pok Katona, Linda Saghy, Peter Newton, Kathryn Somogyi, Peter Lamsa, Karri P. Brain Struct Funct Original Article Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. We investigated synaptically-evoked suprathreshold excitation of identified hippocampal neurons in the CA1 area of urethane-anaesthetized rats. Neurons were recorded extracellularly with glass microelectrodes, and labelled with neurobiotin for anatomical analyses. Single-shock electrical stimulation of afferents from the contralateral CA1 elicited postsynaptic action potentials with monosynaptic features showing short delay (9.95 ± 0.41 ms) and small jitter in 13 neurons through the commissural pathway. Theta-burst stimulation (TBS) generated LTP of the synaptically-evoked spike probability in pyramidal cells, and in a bistratified cell and two unidentified fast-spiking interneurons. On the contrary, PV+ basket cells and NOS+ ivy cells exhibited either LTD or LTP. An identified axo-axonic cell failed to show long-term change in its response to stimulation. Discharge of the cells did not explain whether LTP or LTD was generated. For the fast-spiking interneurons, as a group, no correlation was found between plasticity and local field potential oscillations (1–3 or 3–6 Hz components) recorded immediately prior to TBS. The results demonstrate activity-induced long-term plasticity in synaptic excitation of hippocampal PV+ and NOS+ interneurons in vivo. Physiological and pathological activity patterns in vivo may generate similar plasticity in these interneurons. Springer Berlin Heidelberg 2016-10-25 2017 /pmc/articles/PMC5406446/ /pubmed/27783219 http://dx.doi.org/10.1007/s00429-016-1309-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Lau, Petrina Yau-Pok
Katona, Linda
Saghy, Peter
Newton, Kathryn
Somogyi, Peter
Lamsa, Karri P.
Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
title Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
title_full Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
title_fullStr Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
title_full_unstemmed Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
title_short Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
title_sort long-term plasticity in identified hippocampal gabaergic interneurons in the ca1 area in vivo
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406446/
https://www.ncbi.nlm.nih.gov/pubmed/27783219
http://dx.doi.org/10.1007/s00429-016-1309-7
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