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The lymphoid system: a review of species differences

While an understanding of the structure and function of a generically described immune system is essential in contemporary biomedicine, it is clear that a one-size-fits-all approach applied across multiple species is fraught with contradictions and inconsistencies. Nevertheless, the breakthroughs ac...

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Autor principal: Haley, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406590/
https://www.ncbi.nlm.nih.gov/pubmed/28458449
http://dx.doi.org/10.1293/tox.2016-0075
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author Haley, Patrick J.
author_facet Haley, Patrick J.
author_sort Haley, Patrick J.
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description While an understanding of the structure and function of a generically described immune system is essential in contemporary biomedicine, it is clear that a one-size-fits-all approach applied across multiple species is fraught with contradictions and inconsistencies. Nevertheless, the breakthroughs achieved in immunology following the application of observations in murine systems to that of man have been pivotal in the advancement of biology and human medicine. However, as additional species have been used to further address biologic and safety assessment questions relative to the structure and function of the immune system, it has become clear that there are differences across species, gender, age and strain that must be considered. The meaningfulness of these differences must be determined on a case-by-case basis. This review article attempts to collect, consolidate and discuss some of these species differences thereby aiding in the accurate placement of new observations in a proper immunobiological and immunopathological perspective.
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spelling pubmed-54065902017-04-28 The lymphoid system: a review of species differences Haley, Patrick J. J Toxicol Pathol Review While an understanding of the structure and function of a generically described immune system is essential in contemporary biomedicine, it is clear that a one-size-fits-all approach applied across multiple species is fraught with contradictions and inconsistencies. Nevertheless, the breakthroughs achieved in immunology following the application of observations in murine systems to that of man have been pivotal in the advancement of biology and human medicine. However, as additional species have been used to further address biologic and safety assessment questions relative to the structure and function of the immune system, it has become clear that there are differences across species, gender, age and strain that must be considered. The meaningfulness of these differences must be determined on a case-by-case basis. This review article attempts to collect, consolidate and discuss some of these species differences thereby aiding in the accurate placement of new observations in a proper immunobiological and immunopathological perspective. Japanese Society of Toxicologic Pathology 2016-12-24 2017-04 /pmc/articles/PMC5406590/ /pubmed/28458449 http://dx.doi.org/10.1293/tox.2016-0075 Text en ©2017 The Japanese Society of Toxicologic Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Haley, Patrick J.
The lymphoid system: a review of species differences
title The lymphoid system: a review of species differences
title_full The lymphoid system: a review of species differences
title_fullStr The lymphoid system: a review of species differences
title_full_unstemmed The lymphoid system: a review of species differences
title_short The lymphoid system: a review of species differences
title_sort lymphoid system: a review of species differences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406590/
https://www.ncbi.nlm.nih.gov/pubmed/28458449
http://dx.doi.org/10.1293/tox.2016-0075
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