Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions

The structure of the new enhancer En1A of the 1A region of the X chromosome of D. melanogaster was investigated. Two distinct regulatory elements were found. The first element is responsible for transcription activation, and the second element provides specific interaction with the promoter of the y...

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Autores principales: Melnikova, L. S., Pomerantseva, E. A., Molodina, V.V., Georgiev, P. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406666/
https://www.ncbi.nlm.nih.gov/pubmed/28461980
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author Melnikova, L. S.
Pomerantseva, E. A.
Molodina, V.V.
Georgiev, P. G.
author_facet Melnikova, L. S.
Pomerantseva, E. A.
Molodina, V.V.
Georgiev, P. G.
author_sort Melnikova, L. S.
collection PubMed
description The structure of the new enhancer En1A of the 1A region of the X chromosome of D. melanogaster was investigated. Two distinct regulatory elements were found. The first element is responsible for transcription activation, and the second element provides specific interaction with the promoter of the yellow gene. The findings support the hypothesis of a modular structure for enhancers, including certain sequences that bind transcription activators and special communication elements providing long-distance enhancer-promoter interaction.
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spelling pubmed-54066662017-05-01 Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions Melnikova, L. S. Pomerantseva, E. A. Molodina, V.V. Georgiev, P. G. Acta Naturae Research Article The structure of the new enhancer En1A of the 1A region of the X chromosome of D. melanogaster was investigated. Two distinct regulatory elements were found. The first element is responsible for transcription activation, and the second element provides specific interaction with the promoter of the yellow gene. The findings support the hypothesis of a modular structure for enhancers, including certain sequences that bind transcription activators and special communication elements providing long-distance enhancer-promoter interaction. A.I. Gordeyev 2017 /pmc/articles/PMC5406666/ /pubmed/28461980 Text en Copyright ® 2017 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Melnikova, L. S.
Pomerantseva, E. A.
Molodina, V.V.
Georgiev, P. G.
Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions
title Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions
title_full Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions
title_fullStr Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions
title_full_unstemmed Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions
title_short Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance Enhancer-Promoter Interactions
title_sort mapping the d.melanogaster en1a enhancer modules responsible for transcription activation and long-distance enhancer-promoter interactions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406666/
https://www.ncbi.nlm.nih.gov/pubmed/28461980
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