Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative

A novel compound, 3,3’-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell’s surfa...

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Autores principales: Novoselova, E.A., Riabova, O.B., Leneva, I.A., Nesterenko, V.G., Bolgarin, R.N., Makarov, V.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406667/
https://www.ncbi.nlm.nih.gov/pubmed/28461981
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author Novoselova, E.A.
Riabova, O.B.
Leneva, I.A.
Nesterenko, V.G.
Bolgarin, R.N.
Makarov, V.A.
author_facet Novoselova, E.A.
Riabova, O.B.
Leneva, I.A.
Nesterenko, V.G.
Bolgarin, R.N.
Makarov, V.A.
author_sort Novoselova, E.A.
collection PubMed
description A novel compound, 3,3’-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell’s surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses.
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spelling pubmed-54066672017-05-01 Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative Novoselova, E.A. Riabova, O.B. Leneva, I.A. Nesterenko, V.G. Bolgarin, R.N. Makarov, V.A. Acta Naturae Research Article A novel compound, 3,3’-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell’s surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses. A.I. Gordeyev 2017 /pmc/articles/PMC5406667/ /pubmed/28461981 Text en Copyright ® 2017 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Novoselova, E.A.
Riabova, O.B.
Leneva, I.A.
Nesterenko, V.G.
Bolgarin, R.N.
Makarov, V.A.
Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
title Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
title_full Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
title_fullStr Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
title_full_unstemmed Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
title_short Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
title_sort antiretroviral activity of a novel pyrimidyl-di(diazaspiroalkane) derivative
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406667/
https://www.ncbi.nlm.nih.gov/pubmed/28461981
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