Cargando…
The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma
Despite the development of novel treatments in the past 15 years, many blood cancers still remain ultimately fatal and difficult to treat, particularly acute myeloid leukaemia (AML) and multiple myeloma (MM). While significant progress has been made characterising small-scale genetic mutations and l...
Autores principales: | Piddock, Rachel E., Bowles, Kristian M., Rushworth, Stuart A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406704/ https://www.ncbi.nlm.nih.gov/pubmed/28350342 http://dx.doi.org/10.3390/cancers9040029 |
Ejemplares similares
-
PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment
por: Piddock, R E, et al.
Publicado: (2017) -
Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection
por: Pillinger, Genevra, et al.
Publicado: (2016) -
Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC
por: Piddock, Rachel E., et al.
Publicado: (2018) -
Bone Marrow Senescence and the Microenvironment of Hematological Malignancies
por: Hellmich, Charlotte, et al.
Publicado: (2020) -
Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche
por: Maynard, Rebecca S., et al.
Publicado: (2022)