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Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside

The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fra...

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Autores principales: Blindbæk, Søren Leer, Torp, Thomas Lee, Lundberg, Kristian, Soelberg, Kerstin, Vergmann, Anna Stage, Poulsen, Christina Døfler, Frydkjaer-Olsen, Ulrik, Broe, Rebecca, Rasmussen, Malin Lundberg, Wied, Jimmi, Lind, Majbrit, Vestergaard, Anders Højslet, Peto, Tunde, Grauslund, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406729/
https://www.ncbi.nlm.nih.gov/pubmed/28491870
http://dx.doi.org/10.1155/2017/2562759
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author Blindbæk, Søren Leer
Torp, Thomas Lee
Lundberg, Kristian
Soelberg, Kerstin
Vergmann, Anna Stage
Poulsen, Christina Døfler
Frydkjaer-Olsen, Ulrik
Broe, Rebecca
Rasmussen, Malin Lundberg
Wied, Jimmi
Lind, Majbrit
Vestergaard, Anders Højslet
Peto, Tunde
Grauslund, Jakob
author_facet Blindbæk, Søren Leer
Torp, Thomas Lee
Lundberg, Kristian
Soelberg, Kerstin
Vergmann, Anna Stage
Poulsen, Christina Døfler
Frydkjaer-Olsen, Ulrik
Broe, Rebecca
Rasmussen, Malin Lundberg
Wied, Jimmi
Lind, Majbrit
Vestergaard, Anders Højslet
Peto, Tunde
Grauslund, Jakob
author_sort Blindbæk, Søren Leer
collection PubMed
description The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes.
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spelling pubmed-54067292017-05-10 Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside Blindbæk, Søren Leer Torp, Thomas Lee Lundberg, Kristian Soelberg, Kerstin Vergmann, Anna Stage Poulsen, Christina Døfler Frydkjaer-Olsen, Ulrik Broe, Rebecca Rasmussen, Malin Lundberg Wied, Jimmi Lind, Majbrit Vestergaard, Anders Højslet Peto, Tunde Grauslund, Jakob J Diabetes Res Review Article The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes. Hindawi 2017 2017-04-13 /pmc/articles/PMC5406729/ /pubmed/28491870 http://dx.doi.org/10.1155/2017/2562759 Text en Copyright © 2017 Søren Leer Blindbæk et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Blindbæk, Søren Leer
Torp, Thomas Lee
Lundberg, Kristian
Soelberg, Kerstin
Vergmann, Anna Stage
Poulsen, Christina Døfler
Frydkjaer-Olsen, Ulrik
Broe, Rebecca
Rasmussen, Malin Lundberg
Wied, Jimmi
Lind, Majbrit
Vestergaard, Anders Højslet
Peto, Tunde
Grauslund, Jakob
Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside
title Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside
title_full Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside
title_fullStr Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside
title_full_unstemmed Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside
title_short Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside
title_sort noninvasive retinal markers in diabetic retinopathy: advancing from bench towards bedside
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406729/
https://www.ncbi.nlm.nih.gov/pubmed/28491870
http://dx.doi.org/10.1155/2017/2562759
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