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The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects

c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dys...

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Autores principales: Nguyen, Lynh, Papenhausen, Peter, Shao, Haipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406863/
https://www.ncbi.nlm.nih.gov/pubmed/28379189
http://dx.doi.org/10.3390/genes8040116
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author Nguyen, Lynh
Papenhausen, Peter
Shao, Haipeng
author_facet Nguyen, Lynh
Papenhausen, Peter
Shao, Haipeng
author_sort Nguyen, Lynh
collection PubMed
description c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to overexpression of intact c-MYC protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes. Dysregulation of c-MYC in B-cell lymphomas occurs either as a primary event in Burkitt lymphoma, or secondarily in aggressive lymphomas such as diffuse large B-cell lymphoma, plasmablastic lymphoma, mantle cell lymphoma, or double-hit lymphoma. Secondary c-MYC changes include gene translocation and gene amplification, occurring against a background of complex karyotype, and most often confer aggressive clinical behavior, as evidenced in the double-hit lymphomas. In low-grade B-cell lymphomas, acquisition of c-MYC rearrangement usually results in transformation into highly aggressive lymphomas, with some exceptions. In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and diagnosis in specific types of B-cell lymphoma.
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spelling pubmed-54068632017-04-27 The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects Nguyen, Lynh Papenhausen, Peter Shao, Haipeng Genes (Basel) Review c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to overexpression of intact c-MYC protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes. Dysregulation of c-MYC in B-cell lymphomas occurs either as a primary event in Burkitt lymphoma, or secondarily in aggressive lymphomas such as diffuse large B-cell lymphoma, plasmablastic lymphoma, mantle cell lymphoma, or double-hit lymphoma. Secondary c-MYC changes include gene translocation and gene amplification, occurring against a background of complex karyotype, and most often confer aggressive clinical behavior, as evidenced in the double-hit lymphomas. In low-grade B-cell lymphomas, acquisition of c-MYC rearrangement usually results in transformation into highly aggressive lymphomas, with some exceptions. In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and diagnosis in specific types of B-cell lymphoma. MDPI 2017-04-05 /pmc/articles/PMC5406863/ /pubmed/28379189 http://dx.doi.org/10.3390/genes8040116 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen, Lynh
Papenhausen, Peter
Shao, Haipeng
The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
title The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
title_full The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
title_fullStr The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
title_full_unstemmed The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
title_short The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
title_sort role of c-myc in b-cell lymphomas: diagnostic and molecular aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406863/
https://www.ncbi.nlm.nih.gov/pubmed/28379189
http://dx.doi.org/10.3390/genes8040116
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