De novo assembly of highly polymorphic metagenomic data using in situ generated reference sequences and a novel BLAST-based assembly pipeline

BACKGROUND: The accuracy of metagenomic assembly is usually compromised by high levels of polymorphism due to divergent reads from the same genomic region recognized as different loci when sequenced and assembled together. A viral quasispecies is a group of abundant and diversified genetically relat...

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Detalles Bibliográficos
Autores principales: Lin, You-Yu, Hsieh, Chia-Hung, Chen, Jiun-Hong, Lu, Xuemei, Kao, Jia-Horng, Chen, Pei-Jer, Chen, Ding-Shinn, Wang, Hurng-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406902/
https://www.ncbi.nlm.nih.gov/pubmed/28446139
http://dx.doi.org/10.1186/s12859-017-1630-z

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