Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

BACKGROUND: Both mTOR and Skp2 play critical roles in gastric cancer (GC) tumorigenesis. However, potential mechanisms for the association between these two proteins remains unidentified. METHODS: The regulatory role for mTORC1 in Skp2 stability was tested using ubiquitination assay. The functions o...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Qirong, Liu, Jianjun, Gong, Zhaohui, Chen, Shangxiang, Chen, Shuai, Li, Xiaoxing, Lu, Yue, Zhu, Xiaofeng, Lin, Hui-kuan, Xu, Dazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407005/
https://www.ncbi.nlm.nih.gov/pubmed/28446188
http://dx.doi.org/10.1186/s12943-017-0649-0

Ejemplares similares

Ejemplares similares