Biosynthesis, Characterization, and Biological Activities of Iron Nanoparticles using Sesamum indicum Seeds Extract

BACKGROUND: Iron nanoparticles (FeNPs) have got many biomedical and health applications because of biocompatible and nontoxic nature to humans. OBJECTIVE: To synthesize the FeNPs using natural sources. MATERIALS AND METHODS: In this study, simple and economical procedure was adopted for FeNPs synthesis. Sesame seeds were processed to obtain seed extract as a biological material for FeNPs production. FeNPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopic. RESULTS: The average diameter of these FeNPs was 99 nm. These nanoparticles showed significant anti-typhoid activity (30 mm zone of inhibition) as compared to ciprofloxacin (32 mm) as standard. Furthermore, in vitro alpha-amylase inhibitory assay also showed moderate antidiabetic activity with more than 50% inhibition. CONCLUSION: This study would be helpful in understanding of nanoparticles synthesis from natural sources and ultimately will be used as potential alternative therapeutic agents. SUMMARY: Iron nanoparticles (FeNPs) were synthesized by Sesamum indicum seeds. FeNPs were characterized by scanning electron microscope with average diameter of 99 nm. These FeNPs are effective against Salmonella typhi, a causative agent of typhoid. These FeNPs can be used as antidiabetic agent. Abbreviations used: FeNPs: Iron Nano Particles; SEM: Scanning Electron Microscopy; MIC: Minimum Inhibitory Concentration; S. indicum: Sesamum Indicum.