Multiple Aggregation Pathways in Human γS-Crystallin and Its Aggregation-Prone G18V Variant

PURPOSE: Cataract results from the formation of light-scattering precipitates due to point mutations or accumulated damage in the structural crystallins of the eye lens. Although excised cataracts are predominantly amorphous, in vitro studies show that crystallins are capable of adopting a variety o...

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Detalles Bibliográficos
Autores principales: Roskamp, Kyle W., Montelongo, David M., Anorma, Chelsea D., Bandak, Diana N., Chua, Janine A., Malecha, Kurtis T., Martin, Rachel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Lens
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407245/
https://www.ncbi.nlm.nih.gov/pubmed/28444328
http://dx.doi.org/10.1167/iovs.16-20621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407245/
https://www.ncbi.nlm.nih.gov/pubmed/28444328
http://dx.doi.org/10.1167/iovs.16-20621

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