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Multiple Aggregation Pathways in Human γS-Crystallin and Its Aggregation-Prone G18V Variant
PURPOSE: Cataract results from the formation of light-scattering precipitates due to point mutations or accumulated damage in the structural crystallins of the eye lens. Although excised cataracts are predominantly amorphous, in vitro studies show that crystallins are capable of adopting a variety o...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Association for Research in Vision and Ophthalmology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407245/ https://www.ncbi.nlm.nih.gov/pubmed/28444328 http://dx.doi.org/10.1167/iovs.16-20621 |