Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy

This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood–retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel appr...

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Detalles Bibliográficos
Autores principales: Ebneter, Andreas, Kokona, Despina, Jovanovic, Joël, Zinkernagel, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407246/
https://www.ncbi.nlm.nih.gov/pubmed/28458957
http://dx.doi.org/10.1167/tvst.6.2.10
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author Ebneter, Andreas
Kokona, Despina
Jovanovic, Joël
Zinkernagel, Martin S.
author_facet Ebneter, Andreas
Kokona, Despina
Jovanovic, Joël
Zinkernagel, Martin S.
author_sort Ebneter, Andreas
collection PubMed
description This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood–retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel approach to modulate ocular inflammatory processes.
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spelling pubmed-54072462017-04-30 Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy Ebneter, Andreas Kokona, Despina Jovanovic, Joël Zinkernagel, Martin S. Transl Vis Sci Technol Letter to the Editor This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood–retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel approach to modulate ocular inflammatory processes. The Association for Research in Vision and Ophthalmology 2017-04-19 /pmc/articles/PMC5407246/ /pubmed/28458957 http://dx.doi.org/10.1167/tvst.6.2.10 Text en Copyright 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Letter to the Editor
Ebneter, Andreas
Kokona, Despina
Jovanovic, Joël
Zinkernagel, Martin S.
Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy
title Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy
title_full Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy
title_fullStr Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy
title_full_unstemmed Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy
title_short Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy
title_sort dramatic effect of oral csf-1r kinase inhibitor on retinal microglia revealed by in vivo scanning laser ophthalmoscopy
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407246/
https://www.ncbi.nlm.nih.gov/pubmed/28458957
http://dx.doi.org/10.1167/tvst.6.2.10
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