Cargando…

Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy

This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood–retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel appr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ebneter, Andreas, Kokona, Despina, Jovanovic, Joël, Zinkernagel, Martin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407246/ https://www.ncbi.nlm.nih.gov/pubmed/28458957 http://dx.doi.org/10.1167/tvst.6.2.10

Ejemplares similares

Inhibition of inflammatory cells delays retinal degeneration in experimental retinal vein occlusion in mice
por: Jovanovic, Joël, et al.
Publicado: (2019)

Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography
por: Giannakaki-Zimmermann, Helena, et al.
Publicado: (2016)

Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation
por: Kokona, Despina, et al.
Publicado: (2018)

FLUORESCENCE LIFETIME IMAGING OPHTHALMOSCOPY: Findings After Surgical Reattachment of Macula-Off Rhegmatogenous Retinal Detachment
por: Jaggi, Damian, et al.
Publicado: (2020)

Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy
por: Karst, Sonja G., et al.
Publicado: (2018)

In vivo analysis of onset and progression of retinal degeneration in the Nr2e3(rd7/rd7) mouse model of enhanced S-cone sensitivity syndrome
por: Venturini, Giulia, et al.
Publicado: (2021)

Author Correction: In vivo analysis of onset and progression of retinal degeneration in the Nr2e3(rd7/rd7) mouse model of enhanced S-cone sensitivity syndrome
por: Venturini, Giulia, et al.
Publicado: (2021)

Ultrasmall spot size scanning laser ophthalmoscopy
por: Vohnsen, Brian, et al.
Publicado: (2011)

Scanning laser ophthalmoscopy retroillumination: applications and illusions
por: Mainster, Martin A., et al.
Publicado: (2022)

Photoacoustic ophthalmoscopy for in vivo retinal imaging
por: Jiao, Shuliang, et al.
Publicado: (2010)

Confocal scanning laser ophthalmoscopy in glaucoma diagnosis and management
por: Alexandrescu, C, et al.
Publicado: (2010)

An Automated Approach for Localizing Retinal Blood Vessels in Confocal Scanning Laser Ophthalmoscopy Fundus Images
por: Kromer, Robert, et al.
Publicado: (2016)

Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Retinal Nerve Fiber Layer Measurements of Glaucoma Patients
por: Fanihagh, Farsad, et al.
Publicado: (2015)

Real-Time Imaging of Retinal Cell Apoptosis by Confocal Scanning Laser Ophthalmoscopy and Its Role in Glaucoma
por: Yang, Elizabeth, et al.
Publicado: (2018)

Characterization of Inner Retinal Hyperreflective Alterations in Early Cognitive Impairment on Adaptive Optics Scanning Laser Ophthalmoscopy
por: Zhang, Yi Stephanie, et al.
Publicado: (2019)

Expansion of retinal nerve fiber bundle narrowing in glaucoma: An adaptive optics scanning laser ophthalmoscopy study
por: Hasegawa, Tomoko, et al.
Publicado: (2020)

Peripheral Retinal Degenerations and Idiopathic Epiretinal Membrane: Analysis with Ultra-Wide-Field Scanning Laser Ophthalmoscopy
por: Ulfik-Dembska, Klaudia, et al.
Publicado: (2021)

Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure
por: Tsioti, Ioanna, et al.
Publicado: (2023)

Macular Cone Abnormalities in Retinitis Pigmentosa with Preserved Central Vision Using Adaptive Optics Scanning Laser Ophthalmoscopy
por: Makiyama, Yukiko, et al.
Publicado: (2013)

Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy
por: Arichika, Shigeta, et al.
Publicado: (2015)

Imaging of Retinal Vascular Layers: Adaptive Optics Scanning Laser Ophthalmoscopy Versus Optical Coherence Tomography Angiography
por: Kaizu, Yoshihiro, et al.
Publicado: (2017)

Retinal Blood Velocity and Flow in Early Diabetes and Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy
por: Palochak, Cherilyn Mae A., et al.
Publicado: (2019)

Analysis of individual cone-photoreceptor directionality using scanning laser ophthalmoscopy
por: Rativa, Diego, et al.
Publicado: (2011)

Retromode Scanning Laser Ophthalmoscopy for Choroidal Nevi: A Preliminary Study
por: Azzolini, Claudia, et al.
Publicado: (2023)

FLUORESCENCE LIFETIME IMAGING OPHTHALMOSCOPY AS PREDICTOR OF LONG-TERM FUNCTIONAL OUTCOME IN MACULA-OFF RHEGMATOGENOUS RETINAL DETACHMENT
por: Jaggi, Damian, et al.
Publicado: (2022)

Fluorescence lifetime imaging ophthalmoscopy
por: Dysli, Chantal, et al.
Publicado: (2017)

Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy
por: Chui, Toco Y. P., et al.
Publicado: (2016)

High-Resolution Imaging of the Retinal Nerve Fiber Layer in Normal Eyes Using Adaptive Optics Scanning Laser Ophthalmoscopy
por: Takayama, Kohei, et al.
Publicado: (2012)

Relationship Between Foveal Cone Structure and Visual Acuity Measured With Adaptive Optics Scanning Laser Ophthalmoscopy in Retinal Degeneration
por: Foote, Katharina G., et al.
Publicado: (2018)

Scanning Laser Ophthalmoscopy Retromode Imaging Compared to Fundus Autofluorescence in Detecting Outer Retinal Features in Central Serous Chorioretinopathy
por: Giansanti, Fabrizio, et al.
Publicado: (2022)

Comparison of Widefield Laser Ophthalmoscopy and ETDRS Retinal Area for Diabetic Retinopathy
por: Ashraf, Mohamed, et al.
Publicado: (2022)

The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy
por: Zhang, Pengfei, et al.
Publicado: (2016)

The Influence of Cataract on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO)
por: Lincke, Joel-Benjamin, et al.
Publicado: (2021)

Modeling the foveal cone mosaic imaged with adaptive optics scanning laser ophthalmoscopy
por: Putnam, Nicole M., et al.
Publicado: (2010)

Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma
por: Choudhari, Nikhil S, et al.
Publicado: (2022)

Retro-Mode Scanning Laser Ophthalmoscopy Planning for Navigated Macular Laser Photocoagulation in Macular Edema
por: Boiko, Ernest V., et al.
Publicado: (2016)

Dark-Field Scanning Laser Ophthalmoscopy for Prediction of Central Serous Chorioretinopathy Responsiveness to Laser Therapy
por: Kulikov, Alexei N., et al.
Publicado: (2022)

High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates
por: Yamaguchi, Muneo, et al.
Publicado: (2016)

Estimation of Diabetic Retinal Microaneurysm Perfusion Parameters Based on Computational Fluid Dynamics Modeling of Adaptive Optics Scanning Laser Ophthalmoscopy
por: Bernabeu, Miguel O., et al.
Publicado: (2018)

Changes on Confocal Scanning Laser Ophthalmoscopy with the Heidelberg Retinal Tomography after a Cardiac Catheterism in a Patient with Progressive Glaucoma
por: Valera-Cornejo, Diego Alejandro, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b3p6dgle77s2e8fidjr72u7gvp