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Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P
INTRODUCTION: Transurethral resection of the prostate is one of the most frequent urological procedures. Urinary tract infections represent major sequelae, but data about antibiotic prophylaxis in TUR-P are controversial and outdated. MATERIAL AND METHODS: We conducted a retrospective multicentre st...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Urological Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407338/ https://www.ncbi.nlm.nih.gov/pubmed/28461999 http://dx.doi.org/10.5173/ceju.2017.941 |
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author | Schneidewind, Laila Kranz, Jennifer Schlager, Daniel Barski, Dimitri Mühlsteadt, Sandra Grabbert, Markus Queissert, Fabian Frank, Tanja Pelzer, Alexandre Egon |
author_facet | Schneidewind, Laila Kranz, Jennifer Schlager, Daniel Barski, Dimitri Mühlsteadt, Sandra Grabbert, Markus Queissert, Fabian Frank, Tanja Pelzer, Alexandre Egon |
author_sort | Schneidewind, Laila |
collection | PubMed |
description | INTRODUCTION: Transurethral resection of the prostate is one of the most frequent urological procedures. Urinary tract infections represent major sequelae, but data about antibiotic prophylaxis in TUR-P are controversial and outdated. MATERIAL AND METHODS: We conducted a retrospective multicentre study of TUR-P in ten German hospitals. Primary endpoints were epidemiological and outcome data of TUR-P. Secondary endpoints were the identification of factors associated with febrile UTIs and sepsis after TUR-P. RESULTS: We included 444 patients with a median age of 71.0 years. Nearly every patient (93.5%) received some kind of antibiotic prophylaxis. Complication rates were 4.9% for febrile UTIs and 2.3% sepsis. Significant risk factors associated with febrile UTIs were pre-existing risk factors for UTIs (p = 0.035) and a duration of catheterization of more than three days (p <0.0001). Significant risk factors for sepsis were duration of surgery of more than 60 minutes (p = 0.030) and again a duration of catheterization of more than three days (p <0.0001). Interestingly, 50.8% of the cases had evidence of chronic prostatitis in their histological specimen. This evidence of chronic prostatitis was significantly associated with febrile UTIs (p = 0.019) and sepsis (p = 0.018). CONCLUSIONS: Duration of catheterization is one of the major risk factors for infectious complications after TUR-P. Antibiotic prophylaxis in TUR-P needs prospective investigation. These future studies should also address chronic prostatitis a priori. |
format | Online Article Text |
id | pubmed-5407338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Polish Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-54073382017-05-01 Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P Schneidewind, Laila Kranz, Jennifer Schlager, Daniel Barski, Dimitri Mühlsteadt, Sandra Grabbert, Markus Queissert, Fabian Frank, Tanja Pelzer, Alexandre Egon Cent European J Urol Original Paper INTRODUCTION: Transurethral resection of the prostate is one of the most frequent urological procedures. Urinary tract infections represent major sequelae, but data about antibiotic prophylaxis in TUR-P are controversial and outdated. MATERIAL AND METHODS: We conducted a retrospective multicentre study of TUR-P in ten German hospitals. Primary endpoints were epidemiological and outcome data of TUR-P. Secondary endpoints were the identification of factors associated with febrile UTIs and sepsis after TUR-P. RESULTS: We included 444 patients with a median age of 71.0 years. Nearly every patient (93.5%) received some kind of antibiotic prophylaxis. Complication rates were 4.9% for febrile UTIs and 2.3% sepsis. Significant risk factors associated with febrile UTIs were pre-existing risk factors for UTIs (p = 0.035) and a duration of catheterization of more than three days (p <0.0001). Significant risk factors for sepsis were duration of surgery of more than 60 minutes (p = 0.030) and again a duration of catheterization of more than three days (p <0.0001). Interestingly, 50.8% of the cases had evidence of chronic prostatitis in their histological specimen. This evidence of chronic prostatitis was significantly associated with febrile UTIs (p = 0.019) and sepsis (p = 0.018). CONCLUSIONS: Duration of catheterization is one of the major risk factors for infectious complications after TUR-P. Antibiotic prophylaxis in TUR-P needs prospective investigation. These future studies should also address chronic prostatitis a priori. Polish Urological Association 2017-01-18 2017 /pmc/articles/PMC5407338/ /pubmed/28461999 http://dx.doi.org/10.5173/ceju.2017.941 Text en Copyright by Polish Urological Association http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Schneidewind, Laila Kranz, Jennifer Schlager, Daniel Barski, Dimitri Mühlsteadt, Sandra Grabbert, Markus Queissert, Fabian Frank, Tanja Pelzer, Alexandre Egon Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P |
title | Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P |
title_full | Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P |
title_fullStr | Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P |
title_full_unstemmed | Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P |
title_short | Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P |
title_sort | mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in tur-p |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407338/ https://www.ncbi.nlm.nih.gov/pubmed/28461999 http://dx.doi.org/10.5173/ceju.2017.941 |
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